標題: The treatment of propofol induced the TGF-beta 1 expression in human endothelial cells to suppress endocytosis activities of monocytes
作者: Li, Chi-Han
Lee, Ru-Ping
Lin, Yu-Ling
Lin, Chen-Si
Hsu, Bang-Gee
Tseng, Feng-Jen
Chen, Yu-Cheng
Liao, Kuang-Wen
Yang, Fwu-Lin
生物科技學系
分子醫學與生物工程研究所
Department of Biological Science and Technology
Institute of Molecular Medicine and Bioengineering
關鍵字: Propofol;TGF-beta 1;Endothelial cells;Monocytes;Immunosuppression
公開日期: 1-十二月-2010
摘要: Propofol anesthesia and sedation are known to downregulate the functions of many hematopoietic cells, such as macrophages and neutrophils, in vivo. However, the effects of propofol on secretion of the regulatory cytokine transforming growth factor beta 1 (TGF-beta 1) in vivo are unknown. In this study, the effects of propofol on TGF-beta 1 expression in human peripheral blood mononuclear cells, umbilical vein endothelial cells (HUVECs), lymphocytes (Jurkat) and monocytes (THP-1) were tested. Moreover, these sera were also tested for regulatory activity on monocyte endocytosis with or without treatment with the TGF-beta 1 pathway inhibitor SB431542. Propofol raised levels of both total and activated TGF-beta 1 in propofol-treated patient sera after surgical operations. Furthermore, propofol induced secretion of latent TGF-beta 1 in HUVEC cells and enhanced TGF-beta 1 activation in THP-1 and Jurkat cells in vitro. Additionally, sera from propofol-treated patients suppressed monocyte endocytosis ex vivo, an effect that was abrogated by the TGF-beta 1 pathway inhibitor SB431542. (C) 2010 Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.cyto.2010.08.001
http://hdl.handle.net/11536/26308
ISSN: 1043-4666
DOI: 10.1016/j.cyto.2010.08.001
期刊: CYTOKINE
Volume: 52
Issue: 3
起始頁: 203
結束頁: 209
顯示於類別:期刊論文


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