標題: T allele for VEGF gene-460 polymorphism at the 5 ''-untransiated region - Association with a higher susceptibility to endometriosis
作者: Hsieh, YY
Chang, CC
Tsai, FJ
Yeh, LS
Lin, CC
Peng, CT
生物科技學系
Department of Biological Science and Technology
關鍵字: endometriosis;endothelial growth factors;polymorphism (genetics)
公開日期: 1-Jun-2004
摘要: OBJECTIVE: To investigate whether vascular endothelial growth factor (VEGF) gene 5'-UTR-460 polymorphism could be used as a marker of susceptibility to endometriosis. STUDY DESIGN: Women were divided into 2 groups, endometriosis (n = 122) and nonendometriosis (n = 131). Polymorphisms for VEGF were detected by polymerase chain reaction and BstUI (New England Biolabs, Beverly, Massachusetts) restriction enzyme analysis. Genotypes and allelic frequencies between the groups were compared. RESULTS: Proportions of different VEGF polymorphisms in the groups were significantly different. Proportions of cuttable (C) homozygote/heterozygote/uncuttable (T) homozygote for VEGF in the groups were 0144.3155.7% and 0/63.4/36.6%, respectively. A higher percentage of T/T homozygote and T allele was present in the endometriosis population. The proportions of C/T alleles in the groups were 22.1/77.9% and 31.7/68.3%, respectively. CONCLUSION: T/T homozygotes and the T allele of the VEGF-460 gene are associated with a higher risk of endometriosis. Heterozygotes and C allele are related to the lower risk of endometriosis formation. VEGF polymorphism likely contributes to the pathogenesis of endometriosis and may become a useful marker for predicting endometriosis susceptibility.
URI: http://hdl.handle.net/11536/26703
ISSN: 0024-7758
期刊: JOURNAL OF REPRODUCTIVE MEDICINE
Volume: 49
Issue: 6
起始頁: 468
結束頁: 472
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