Design and synthesis of activity probes for glycosidases

完整後設資料紀錄

DC 欄位	值	語言
dc.contributor.author	Tsai, CS	en_US
dc.contributor.author	Li, YK	en_US
dc.contributor.author	Lo, LC	en_US
dc.date.accessioned	2014-12-08T15:41:49Z	-
dc.date.available	2014-12-08T15:41:49Z	-
dc.date.issued	2002-10-17	en_US
dc.identifier.issn	1523-7060	en_US
dc.identifier.uri	http://dx.doi.org/10.1021/ol0265315	en_US
dc.identifier.uri	http://hdl.handle.net/11536/28446	-
dc.description.abstract	[GRAPHICS] A new synthetic route was developed for the preparation of activity probe 1 for beta-glucosidase in this study. The key glycosidation step begins with benzyl p-hydroxyphenylacetate. Benzylic functionalization for the construction of the trapping device was achieved at later stages. Probe 1 was shown to be able to label the target enzyme. This cassette-like design offers great flexibility for future alterations. It would allow the synthetic scheme to expand to other glycosidase probes with different linker/reporter combinations.	en_US
dc.language.iso	en_US	en_US
dc.title	Design and synthesis of activity probes for glycosidases	en_US
dc.type	Article	en_US
dc.identifier.doi	10.1021/ol0265315	en_US
dc.identifier.journal	ORGANIC LETTERS	en_US
dc.citation.volume	4	en_US
dc.citation.issue	21	en_US
dc.citation.spage	3607	en_US
dc.citation.epage	3610	en_US
dc.contributor.department	應用化學系	zh_TW
dc.contributor.department	Department of Applied Chemistry	en_US
dc.identifier.wosnumber	WOS:000178522700015	-
dc.citation.woscount	51	-
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