Synthesis of tacamonine

Title:	Synthesis of tacamonine
Authors:	Ho, TL Gorobets, E 應用化學系 Department of Applied Chemistry
Keywords:	tacamonine;mannich reaction;Beckmann fragmentation
Issue Date:	10-Jun-2002
Abstract:	Tacamonine has been synthesized in 3.2% overall yield from cyclohexanone-4-carboxylic acid ethyleneacetal. The tetrahydro-beta-carboline intermediate was submitted to a Mannich reaction to provide a bridged ring system embodying latent branches of the quinolizidine portion. The final stages included fragmentation and Grignard reaction. (C) 2002 Published by Elsevier Science Ltd.
URI:	http://dx.doi.org/10.1016/S0040-4020(02)00395-2 http://hdl.handle.net/11536/28723
ISSN:	0040-4020
DOI:	10.1016/S0040-4020(02)00395-2
Journal:	TETRAHEDRON
Volume:	58
Issue:	24
Begin Page:	4969
End Page:	4973
Appears in Collections:	Articles

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