Full metadata record
DC FieldValueLanguage
dc.contributor.authorGuu, JAen_US
dc.contributor.authorHsiue, GHen_US
dc.contributor.authorJuang, TMen_US
dc.date.accessioned2014-12-08T15:43:00Z-
dc.date.available2014-12-08T15:43:00Z-
dc.date.issued2002en_US
dc.identifier.issn0920-5063en_US
dc.identifier.urihttp://hdl.handle.net/11536/29127-
dc.identifier.urihttp://dx.doi.org/10.1163/156856202320813846en_US
dc.description.abstractThree kinds of polymeric adriamycin (ADR) conjugates of dextran were synthesized, namely a dextran-Gly-Leu-Gly-ADR (DGLGA) conjugate with a lysosomally degradable tripeptide spacer group, a dextran-Gly-Leu-Gly-ADR-galactosamine (DGLGA-Ga) conjugate with a targeting moiety of galactosamine on DGLGA, and a dextran-C6H10-ADR (DC(6)A) conjugate with a hexamethylen spacer group. The content of the ADR moiety in the polymeric-drug conjugate was about 3 mol%. Enzyme hydrolysis of DGLGA and DC(6)A was carried out by incubation with papain. The total amount of ADR released after 48 h was 43 mol% for DGLGA and less than 1 mol% for DC(6)A. In an in vitro cytotoxicity experiment. the DGLGA-Ga conjugate has higher cytotoxic efficacy than the other conjugates for incubation with Hep-3B cells and consequently. the capability of targeting hepatoma cells of the galactosamine residue was determined. In contrast, for the incubation with SiHa cells of these conjugates, there was no significant cytotoxicity effect. The in vivo cytotoxic efficacy of each conjugate (20 mg ADR equiv./kg) against CT-26 mice colon cells implanted subcutaneously in Balb-C mice was studied. The DGLGA conjugate generated the best therapeutic effect with the presence of long-term survival (LTS) at day 50 (2/6).en_US
dc.language.isoen_USen_US
dc.subjectdextranen_US
dc.subjectpolymeric pro-drugen_US
dc.subjectantitumor activityen_US
dc.subjectadriamycinen_US
dc.subjectgalactosamineen_US
dc.titleSynthesis and biological properties of antitumor-active conjugates of ADR with dextranen_US
dc.typeArticleen_US
dc.identifier.doi10.1163/156856202320813846en_US
dc.identifier.journalJOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITIONen_US
dc.citation.volume13en_US
dc.citation.issue10en_US
dc.citation.spage1135en_US
dc.citation.epage1151en_US
dc.contributor.department應用化學系zh_TW
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.identifier.wosnumberWOS:000180112600006-
dc.citation.woscount5-
Appears in Collections:Articles


Files in This Item:

  1. 000180112600006.pdf

If it is a zip file, please download the file and unzip it, then open index.html in a browser to view the full text content.