Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Liang, Sheng-Fu | en_US |
dc.contributor.author | Liao, Yi-Cheng | en_US |
dc.contributor.author | Shaw, Fu-Zen | en_US |
dc.contributor.author | Chang, Da-Wei | en_US |
dc.contributor.author | Young, Chung-Ping | en_US |
dc.contributor.author | Chiueh, Herming | en_US |
dc.date.accessioned | 2014-12-08T15:43:07Z | - |
dc.date.available | 2014-12-08T15:43:07Z | - |
dc.date.issued | 2011-08-01 | en_US |
dc.identifier.issn | 1741-2560 | en_US |
dc.identifier.uri | http://dx.doi.org/10.1088/1741-2560/8/4/045001 | en_US |
dc.identifier.uri | http://hdl.handle.net/11536/29175 | - |
dc.description.abstract | In this paper numerous alternative treatments in addition to pharmacological therapy are proposed for their use in epileptic patients. Epileptic animal models can play a crucial role in the performance evaluation of new therapeutic techniques. The objective of this research is to first develop various epileptic rat models; second, develop a portable wireless closed-loop seizure controller including on-line seizure detection and real-time electrical stimulation for seizure elimination; and third, apply the developed seizure controller to the animal models to perform on-line seizure elimination. The closed-loop seizure controller was applied to three Long-Evans rats with spontaneous spike-wave discharges (non-convulsive) and three Long-Evans rats with epileptiform activities induced by pentylenetetrazol (PTZ) injection (convulsive) for evaluation. The seizure detection accuracy is greater than 92% (up to 99%), and averaged seizure detection latency is less than 0.6 s for both spontaneous non-convulsive and PTZ-induced convulsive seizures. The average false stimulation rate is 3.1%. Near 30% of PTZ-induced convulsive seizures need more than two times of 0.5 s electrical stimulation for suppression and 90% of the non-convulsive seizures can be suppressed by only one 0.5 s electrical stimulation. | en_US |
dc.language.iso | en_US | en_US |
dc.title | Closed-loop seizure control on epileptic rat models | en_US |
dc.type | Article; Proceedings Paper | en_US |
dc.identifier.doi | 10.1088/1741-2560/8/4/045001 | en_US |
dc.identifier.journal | JOURNAL OF NEURAL ENGINEERING | en_US |
dc.citation.volume | 8 | en_US |
dc.citation.issue | 4 | en_US |
dc.citation.epage | en_US | |
dc.contributor.department | 電機工程學系 | zh_TW |
dc.contributor.department | Department of Electrical and Computer Engineering | en_US |
dc.identifier.wosnumber | WOS:000292962800005 | - |
Appears in Collections: | Conferences Paper |
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