標題: The preventive effects of G115 on balloon injury-induced neointima formation in rats
作者: Wu, CH
Tsai, BR
Hsieh, WT
Chang, GY
Mao, SJT
Chang, WC
生物科技學系
Department of Biological Science and Technology
關鍵字: angioplasty;restenosis;Panax Ginseng;ginsenosides;G115
公開日期: 28-十二月-2001
摘要: After percutaneous transluminal coronary angioplasty (PTCA), 30-50% of the patients may present with restenosis within 6 months. The aim of this study was to search for a preventive remedy against the balloon injury-induced neointima formation. Ginseng, with its wide indications on immune and cardiovascular functions, has prompted us to explore its role in neointima formation. In the present study, we aimed to explore if a standardized Panax Ginseng extract G115 was able to inhibit neointimal formation. With BrdU luminencence assay, maximal proliferation of rat smooth muscle cells was reduced to 24% of control values by G115. Norepinephrine-induced vasocontraction was antagonized in 21% and 44% by 1.44mg/ml and 2.88mg/ml of G115, respectively. Neointima-to-lumen area ratio of balloon-injured rat carotid arteries was reduced 77.3% by G115 as compared to the sham control. These results demonstrate the preventive effects of ginsenosides on angioplasty-mediated neointima formation. (C) 2001 Elsevier Science Inc. All rights reserved.
URI: http://dx.doi.org/10.1016/S0024-3205(01)01442-4
http://hdl.handle.net/11536/29180
ISSN: 0024-3205
DOI: 10.1016/S0024-3205(01)01442-4
期刊: LIFE SCIENCES
Volume: 70
Issue: 6
起始頁: 669
結束頁: 679
顯示於類別:期刊論文


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