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dc.contributor.authorFan, CWen_US
dc.contributor.authorSheu, DLen_US
dc.contributor.authorFan, HAen_US
dc.contributor.authorHsu, KCen_US
dc.contributor.authorChang, CAen_US
dc.contributor.authorChan, ECen_US
dc.date.accessioned2014-12-08T15:43:57Z-
dc.date.available2014-12-08T15:43:57Z-
dc.date.issued2001-04-10en_US
dc.identifier.issn0304-3835en_US
dc.identifier.urihttp://dx.doi.org/10.1016/S0304-3835(01)00416-5en_US
dc.identifier.urihttp://hdl.handle.net/11536/29711-
dc.description.abstractMatrix Gla protein (MGP) is a vitamin K-dependent extracellular matrix protein commonly found in a variety of tissues. In this study, we describe the potential use of MGP gene expression as the tumor marker of colorectal cancer. A decrease in expression of the MGP gene was also discovered in colorectal cancer using differential screening of cDNA libraries. The MGP expression in 80 human colorectal adenocarcinomas was quantified by a Northern blot analysis to better define the expression pattern of MGP in colorectal cancer. The expression of MGP mRNA was reduced in 63 of 80 (79%) colorectal adenocarcinomas (P < 0.001) as compared to the mRNA in adjacent normal tissue, implying that a decrease in MGP expression is associated with colorectal cancer development. The proportion of tumors with downregulated expression of MGP was lower in Duke's A/B than Duke's C/D (34 of 47 versus 26 of 33, respectively) tumors and was lower in moderate differentiation than poor differentiation (44 of 64 versus 16 of 16, respectively). However, chi (2) analysis does not reveal any correlation between a loss of MGP expression and tumor progression or differentiation state. In conclusion, the downregulation of MGP mRNA generally occurs in colorectal adenocarcinomas. Although the role of MGP in cancer development is unknown, the reduced expression of MGP may be used to distinguish the normal colorectal cells from malignant cells. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectvitamin K-dependent proteinen_US
dc.subjectNorthern bloten_US
dc.subjectin situ RNA hybridizationen_US
dc.subjectGla proteinen_US
dc.subjectcDNA libraryen_US
dc.titleDown-regulation of matrix Gla protein messenger RNA in human colorectal adenocarcinomasen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/S0304-3835(01)00416-5en_US
dc.identifier.journalCANCER LETTERSen_US
dc.citation.volume165en_US
dc.citation.issue1en_US
dc.citation.spage63en_US
dc.citation.epage69en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000168440900009-
dc.citation.woscount14-
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