標題: | Synthesis and Characterization of PEG-PCL-PEG Triblock Copolymers as Carriers of Doxorubicin for the Treatment of Breast Cancer |
作者: | Cuong, Nguyen-Van Hsieh, Ming-Fa Chen, Yung-Tsung Liau, Ian 應用化學系分子科學碩博班 Institute of Molecular science |
關鍵字: | nanoparticles;micelles;drug delivery systems;multidrug resistance;monomethoxy poly(ethylene glycol);poly(epsilon-caprolactone) |
公開日期: | 15-九月-2010 |
摘要: | Triblock copolymers of monomethoxy poly(ethylene glycol) (mPEG) and epsilon-caprolactone (CL) were prepared with varying lengths of poly(E-caprolactone) (PCL) compositions and a fixed length of mPEG segment. The molecular characteristics of triblock copolymers were characterized by NMR, gel permeation chromatography (GPC), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and differential scanning calorimetry (DSC). These amphiphilic linear copolymers based on PCL hydrophobic chain and hydrophilic mPEG ending, which can self-assemble into nanoscopic micelles with their hydrophobic cores, encapsulated doxorubicin (DOX) in an aqueous solution. The particle size of prepared micelles was around 40-92 nm. The DOX loading content and DOX loading efficiency were from 3.7-7.4% to 26-49%, respectively. DOX-released profile was pH-dependent and faster at pH 5.4 than pH 7.4. Additionally, the cytotoxicity of DOX-loaded micelles was found to be similar with free DOX in drug-resistant cells (MCF-7/adr). The great amounts of DOX and fast uptake accumulated into the MCF-7/adr cells from DOX-loaded micelles suggest a potential application in cancer chemotherapy. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 117: 3694-3703, 2010 |
URI: | http://dx.doi.org/10.1002/app.32266 http://hdl.handle.net/11536/32188 |
ISSN: | 0021-8995 |
DOI: | 10.1002/app.32266 |
期刊: | JOURNAL OF APPLIED POLYMER SCIENCE |
Volume: | 117 |
Issue: | 6 |
起始頁: | 3694 |
結束頁: | 3703 |
顯示於類別: | 期刊論文 |