可生物相容的聚苯乙烯尿嘧啶奈米纖維之製備與光交聯

Abstract

本研究成功製備出具生物相容性且可光交聯之聚苯乙烯尿嘧啶奈米纖維( Poly 1-(4-vinylbenzyl) uracil )。藉由加入氫氧化鉀可使苯乙烯尿嘧啶微溶於水，再利用水性自由基聚合法聚合出高分子量(Mn=250,550)之聚苯乙烯尿嘧啶。電紡絲法可將其溶於二甲基乙醯胺中置備成奈米纖維，並進一步控制電紡濃度，置備出直徑480 nm無珠狀小球(Bead-free)之奈米纖維。另外，利用254 nm波長的紫外光可使PVBU奈米纖維進行光交聯反應。電子掃描顯微鏡(SEM)和原子力顯微鏡(AFM)影像可得知交聯之纖維浸入二甲基乙醯胺溶液後仍維持其纖維形狀，且於水中也具有良好之尺寸安定性。

In this study, the biocompatible and photocrosslinkable nanofibers were successfully fabricated from the high molecular weight poly(4-vinylbenzyl uracil) (PVBU, Mn= 250,550) synthesized through free radical polymerization in aqueous solution with the 1-(4-vinylbenzyl) uracil treated by potassium hydroxide. Bead-free nanofibers with diameter down to 480 nm can be fabricated through controlling the concentration of PVBU in dimethylacetamide (DMAc) when performing electrospinning. In addition, photocrosslinked PVBU nanofibers can be fabricated through exposing to UV light with wavenumber of 254 nm. Both scanning electron microscopy (SEM) and contact mode imaging via atomic force microscopy (AFM) micrographs indicated that the microstructure of these crosslinked nanofibers remained almost unchanged after immersing in dimethylacetamide and possessed good dimension stability in water.