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dc.contributor.authorHung, Yao-Chingen_US
dc.contributor.authorLee, Jia-Hueyen_US
dc.contributor.authorChen, Huang-Mengen_US
dc.contributor.authorHuang, Guewha Stevenen_US
dc.date.accessioned2014-12-08T15:06:42Z-
dc.date.available2014-12-08T15:06:42Z-
dc.date.issued2010-06-15en_US
dc.identifier.issn0022-0949en_US
dc.identifier.urihttp://dx.doi.org/10.1242/jeb.039768en_US
dc.identifier.urihttp://hdl.handle.net/11536/5262-
dc.description.abstractThe current study investigated the possible effects of static magnetic fields (SMFs) on the developmental and aging processes of Caenorhabditis elegans. Nematodes were grown in the presence of SMFs of strengths varying from 0 to 200 mT. The rate of development and the lifespan were recorded. Treatment with a 200 mT SMF reduced the development time from the L2 to the L3 stage by 20%, from L3 to L4 by 23%, and from L4 to young adult by 31%. After SMF treatment, the average lifespan was reduced from 31 days to 24 days for wild-type nematodes. The up-regulation of clk-1, lim-7, daf-2, unc-3 and age-1 after SMF treatment was verified by quantitative real-time RT-PCR. Apparently, induction of gene expression is selective and dose dependent. The total developmental time was significantly reduced for the lin-4, lin-14, lin-41 and lim-7 mutants, but not for the let-7, clk-1, unc-3 and age-1 mutants. Lifespan analyses revealed that the let-7, unc-3 and age-1 mutants were not affected by SMF treatment. Here we show that SMFs accelerate nematode development and shorten nematode lifespan through pathways associated with let-7, clk-1, unc-3 and age-1.en_US
dc.language.isoen_USen_US
dc.subjectagingen_US
dc.subjectC. elegansen_US
dc.subjectstatic magnetic fieldsen_US
dc.subjectlife cycleen_US
dc.titleEffects of static magnetic fields on the development and aging of Caenorhabditis elegansen_US
dc.typeArticleen_US
dc.identifier.doi10.1242/jeb.039768en_US
dc.identifier.journalJOURNAL OF EXPERIMENTAL BIOLOGYen_US
dc.citation.volume213en_US
dc.citation.issue12en_US
dc.citation.spage2079en_US
dc.citation.epage2085en_US
dc.contributor.department材料科學與工程學系奈米科技碩博班zh_TW
dc.contributor.departmentGraduate Program of Nanotechnology , Department of Materials Science and Engineeringen_US
dc.identifier.wosnumberWOS:000278175700016-
dc.citation.woscount2-
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