親水性二塞吩及三塞吩甲基亞胺衍生物的合成

Abstract

對於二塞吩及三塞吩衍生物的相關研究顯示此等化合物可能成為新 代的 抗癌或抗感染性疾病製劑,但是塞吩化合物大都需在紫外光或日光照射下 才能產生較大的效果,而在沒有照光的情形下,如增加用量或可達到相同結 果.欲降低此類化合物對細胞毒性之副作用及解決試管內(in vitro)与生 體內(in vivo)反應條件的差異,將二塞吩及三塞吩的主要結構上接親水性 側鏈,增加水溶性,或可期待在生體實驗中得到令人滿N的結果.所以本實驗 適合成一系列含親水基的二塞吩及三塞吩的亞胺化合物 ,以提供作為進一 步生體活性試驗用.In advent of studies of bithiophene's and terthiophene's derivatives, we know that these can be the new compounds of choice to protect from cancer or the infections disease. The effect of these compounds can be maximized only in the existance of UV-light or by increasing the dosage. In order to reduce the toxic side effect of these compounds on human cells and reslove the difference of the reactiononditions for in vitro and in vivo, we try to incorporate the major backbones of bithiophene and terthiophene with theydrophilic side chain to increase the solubility in aqueous soluction, and expect the application more effective in vivo. So we synthesize a series of hydrophilic imine of bithiophene and terthiophene compounds, for the subsequent test in vivo.