Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 楊玉瑩 | en_US |
dc.contributor.author | Yu-Ying Yang | en_US |
dc.contributor.author | 吳獻仁 | en_US |
dc.contributor.author | Hsien-Jen Wu | en_US |
dc.date.accessioned | 2014-12-12T02:21:33Z | - |
dc.date.available | 2014-12-12T02:21:33Z | - |
dc.date.issued | 1998 | en_US |
dc.identifier.uri | http://140.113.39.130/cdrfb3/record/nctu/#NT870500045 | en_US |
dc.identifier.uri | http://hdl.handle.net/11536/64823 | - |
dc.description.abstract | 本論文針對新型骨架的掌性含氧籠狀化合物U-2作系統性的研究,分為三部份。 首先,我們利用酵素解析法先得到具有光學活性的起始物(-)-7和(+)-7 (>99% e.e.),之後經臭氧裂解合成出具有光學活性的含氧籠狀化合物(+)-10和(-)-10,再經由不同取代基的轉換,至終我們可以得到化合物U-2的兩個具光學活性且彼此為鏡像的含氧籠狀化合物(-)-17和(+)-17。 接著,我們從化合物U-2產率的增加,得知在臭氧裂解反應完成後加入酸性樹脂(Amberlyst-15),能有助於反應中間物24環化地完全。 最後,我們藉著在臭氧裂解反應中控制臭氧通入的當量,可以初步瞭解化合物U-2生成的反應機構。即二環戊二烯上的兩個雙鍵在臭氧裂解反應進行時,norbornene上的雙鍵會被高選擇性地率先裂解開。 | zh_TW |
dc.description.abstract | Here we have done the systematic research about the novel chiral oxa-cage U-2, and this work can be divided into three parts. First, we utilize enzymatic resolution to obtain the optical active starting material (-)-7 and (+)-7 (>99%). And after ozonolysis of them, we can afford the optical active oxa-cage compounds (+)-10 and (-)-10. Then we have accomplished several transformations with different substituents on the skeleton. At the end , we obtain two optical active compounds (-)-17 and (+)-17, which are the enantiomeric pair of U-2. Second, ozonolysis of the dicyclopentadiene, followed by addition of Amberlyst-15, can help the complete cyclization to afford the tetraoxa-cage compound with higher yield. Finally, by taking control of the amount of entering O3 in ozonolysis, we understand the reaction mechanism from U-1 to U-2 at the first stage. That is , in the progress of ozonolysis, the double bond of norbornene react with ozone with high selectivity. | en_US |
dc.language.iso | zh_TW | en_US |
dc.subject | 籠狀 | zh_TW |
dc.subject | 酵素 | zh_TW |
dc.subject | 掌性 | zh_TW |
dc.subject | 四氧四縮醛 | zh_TW |
dc.subject | cage | en_US |
dc.subject | enzyme | en_US |
dc.subject | enzymatic | en_US |
dc.subject | resolution | en_US |
dc.subject | chiral | en_US |
dc.subject | tetraacetal tetra-oxa | en_US |
dc.title | 利用酵素解析法來合成掌性新型骨架之四氧四縮醛含氧籠狀化合物 | zh_TW |
dc.title | Synthesis of Novel Chiral Tetraacetal Tetraoxa-Cage Compounds by Enzymatic Resolution | en_US |
dc.type | Thesis | en_US |
dc.contributor.department | 應用化學系碩博士班 | zh_TW |
Appears in Collections: | Thesis |