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dc.contributor.authorChen, Chia-Geunen_US
dc.contributor.authorYang, Yun-Liangen_US
dc.contributor.authorTseng, Kuo-Yunen_US
dc.contributor.authorShih, Hsin-Ien_US
dc.contributor.authorLiou, Ci-Hongen_US
dc.contributor.authorLin, Chih-Chaoen_US
dc.contributor.authorLo, Hsiu-Jungen_US
dc.date.accessioned2014-12-08T15:08:46Z-
dc.date.available2014-12-08T15:08:46Z-
dc.date.issued2009-09-01en_US
dc.identifier.issn1087-1845en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.fgb.2009.06.003en_US
dc.identifier.urihttp://hdl.handle.net/11536/6714-
dc.description.abstractOverexpression of MDR1 efflux pump is a major mechanism contributing to drug resistance in Candida albicans, the most common human fungal pathogen. To elucidate the regulatory pathway of drug resistance, we have identified a negative regulator of MDR1 and named it Regulator of Efflux Pump 1 (REP1). Overexpression of REPI in Saccharomyces cerevisiae increased susceptibility to fluconazole. Furthermore, null mutations on REP1 decreased the susceptibility to antifungal drugs in C albicans resulting from increased expression of MDR1 mRNA. Hence, Rep1p is involved in drug resistance by negatively regulating MDR1 in C albicans. (c) 2009 Elsevier Inc. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectEfflux pumpen_US
dc.subjectCandida albicansen_US
dc.subjectDrug resistanceen_US
dc.titleRep1p negatively regulating MDR1 efflux pump involved in drug resistance in Candida albicansen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.fgb.2009.06.003en_US
dc.identifier.journalFUNGAL GENETICS AND BIOLOGYen_US
dc.citation.volume46en_US
dc.citation.issue9en_US
dc.citation.spage714en_US
dc.citation.epage720en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.department分子醫學與生物工程研究所zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentInstitute of Molecular Medicine and Bioengineeringen_US
dc.identifier.wosnumberWOS:000268742100010-
dc.citation.woscount5-
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