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dc.contributor.authorChen, Chun-Chenen_US
dc.contributor.authorLin, Chun-Yuen_US
dc.contributor.authorLo, Yu-Shuen_US
dc.contributor.authorYang, Jinn-Moonen_US
dc.date.accessioned2014-12-08T15:09:13Z-
dc.date.available2014-12-08T15:09:13Z-
dc.date.issued2009-07-01en_US
dc.identifier.issn0305-1048en_US
dc.identifier.urihttp://dx.doi.org/10.1093/nar/gkp309en_US
dc.identifier.urihttp://hdl.handle.net/11536/7026-
dc.description.abstractAs an increasing number of reliable protein-protein interactions (PPIs) become available and high-throughput experimental methods provide systematic identification of PPIs, there is a growing need for fast and accurate methods for discovering homologous PPIs of a newly determined PPI. PPISearch is a web server that rapidly identifies homologous PPIs (called PPI family) and infers transferability of interacting domains and functions of a query protein pair. This server first identifies two homologous families of the query, respectively, by using BLASTP to scan an annotated PPIs database (290 137 PPIs in 576 species), which is a collection of five public databases. We determined homologous PPIs from protein pairs of homologous families when these protein pairs were in the annotated database and have significant joint sequence similarity (E <= 10(-40)) with the query. Using these homologous PPIs across multiple species, this sever infers the conserved domain domain pairs (Pfam and InterPro domains) and function pairs (Gene Ontology annotations). Our results demonstrate that the transferability of conserved domain-domain pairs between homologous PPIs and query pairs is 88% using 103 762 PPI queries, and the transferability of conserved function pairs is 69% based on 106 997 PPI queries. The PPISearch server should be useful for searching homologous PPIs and PPI families across multiple species. The PPISearch server is available through the website at http://gemdock.life.nctu.edu.tw/ppisearch/.en_US
dc.language.isoen_USen_US
dc.titlePPISearch: a web server for searching homologous protein-protein interactions across multiple speciesen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/nar/gkp309en_US
dc.identifier.journalNUCLEIC ACIDS RESEARCHen_US
dc.citation.volume37en_US
dc.citation.issueen_US
dc.citation.spageW369en_US
dc.citation.epageW375en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.department生物資訊及系統生物研究所zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentInstitude of Bioinformatics and Systems Biologyen_US
dc.identifier.wosnumberWOS:000267889100065-
dc.citation.woscount15-
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