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dc.contributor.authorChang, Tzu-Haoen_US
dc.contributor.authorHuang, Hsien-Daen_US
dc.contributor.authorWu, Li-Chingen_US
dc.contributor.authorYeh, Chi-Taen_US
dc.contributor.authorLiu, Baw-Jhiuneen_US
dc.contributor.authorHorng, Jorng-Tzongen_US
dc.date.accessioned2014-12-08T15:09:15Z-
dc.date.available2014-12-08T15:09:15Z-
dc.date.issued2009-07-01en_US
dc.identifier.issn1355-8382en_US
dc.identifier.urihttp://dx.doi.org/10.1261/rna.1623809en_US
dc.identifier.urihttp://hdl.handle.net/11536/7060-
dc.description.abstractRiboswitches are cis-acting genetic regulatory elements within a specific mRNA that can regulate both transcription and translation by interacting with their corresponding metabolites. Recently, an increasing number of riboswitches have been identified in different species and investigated for their roles in regulatory functions. Both the sequence contexts and structural conformations are important characteristics of riboswitches. None of the previously developed tools, such as covariance models (CMs), Riboswitch finder, and RibEx, provide a web server for efficiently searching homologous instances of known riboswitches or considers two crucial characteristics of each riboswitch, such as the structural conformations and sequence contexts of functional regions. Therefore, we developed a systematic method for identifying 12 kinds of riboswitches. The method is implemented and provided as a web server, RiboSW, to efficiently and conveniently identify riboswitches within messenger RNA sequences. The predictive accuracy of the proposed method is comparable with other previous tools. The efficiency of the proposed method for identifying riboswitches was improved in order to achieve a reasonable computational time required for the prediction, which makes it possible to have an accurate and convenient web server for biologists to obtain the results of their analysis of a given mRNA sequence. RiboSW is now available on the web at http://RiboSW.mbc.nctu.edu.tw/.en_US
dc.language.isoen_USen_US
dc.subjectriboswitchen_US
dc.subjectRNA secondary structureen_US
dc.subjectregulatory RNAen_US
dc.titleComputational identification of riboswitches based on RNA conserved functional sequences and conformationsen_US
dc.typeArticleen_US
dc.identifier.doi10.1261/rna.1623809en_US
dc.identifier.journalRNA-A PUBLICATION OF THE RNA SOCIETYen_US
dc.citation.volume15en_US
dc.citation.issue7en_US
dc.citation.spage1426en_US
dc.citation.epage1430en_US
dc.contributor.department生物資訊及系統生物研究所zh_TW
dc.contributor.departmentInstitude of Bioinformatics and Systems Biologyen_US
dc.identifier.wosnumberWOS:000267142400020-
dc.citation.woscount16-
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