標題: Molecular Dynamics insight into the role of tertiary (foldon) interactions on unfolding in Cytochrome c
作者: Tsai, M. Y.
Morozov, A. N.
Chu, K. Y.
Lin, S. H.
交大名義發表
National Chiao Tung University
公開日期: 16-六月-2009
摘要: Hydrogen exchange experiments reveal the existence of a foldon structure in Cytochrome c. We performed constant temperature Molecular Dynamics simulations of Cytochrome c to investigate the macroscopic behavior of the foldons. The results showed that the tertiary interactions in Cytochrome c play an important role in the stabilization of the N- and C-terminal helices. We also observed the macroscopic behavior of a black foldon in the process of thermal unfolding. Our results support that Cytochrome c folding occurs in accordance with the classical pathway concept of Levinthal. (c) 2009 Elsevier B.V. All rights reserved.
URI: http://dx.doi.org/10.1016/j.cplett.2009.05.027
http://hdl.handle.net/11536/7104
ISSN: 0009-2614
DOI: 10.1016/j.cplett.2009.05.027
期刊: CHEMICAL PHYSICS LETTERS
Volume: 475
Issue: 1-3
起始頁: 111
結束頁: 115
顯示於類別:期刊論文


文件中的檔案:

  1. 000266673600023.pdf

若為 zip 檔案,請下載檔案解壓縮後,用瀏覽器開啟資料夾中的 index.html 瀏覽全文。