標題: | Molecular Dynamics insight into the role of tertiary (foldon) interactions on unfolding in Cytochrome c |
作者: | Tsai, M. Y. Morozov, A. N. Chu, K. Y. Lin, S. H. 交大名義發表 National Chiao Tung University |
公開日期: | 16-六月-2009 |
摘要: | Hydrogen exchange experiments reveal the existence of a foldon structure in Cytochrome c. We performed constant temperature Molecular Dynamics simulations of Cytochrome c to investigate the macroscopic behavior of the foldons. The results showed that the tertiary interactions in Cytochrome c play an important role in the stabilization of the N- and C-terminal helices. We also observed the macroscopic behavior of a black foldon in the process of thermal unfolding. Our results support that Cytochrome c folding occurs in accordance with the classical pathway concept of Levinthal. (c) 2009 Elsevier B.V. All rights reserved. |
URI: | http://dx.doi.org/10.1016/j.cplett.2009.05.027 http://hdl.handle.net/11536/7104 |
ISSN: | 0009-2614 |
DOI: | 10.1016/j.cplett.2009.05.027 |
期刊: | CHEMICAL PHYSICS LETTERS |
Volume: | 475 |
Issue: | 1-3 |
起始頁: | 111 |
結束頁: | 115 |
顯示於類別: | 期刊論文 |