利用新穎超分子奈米銀水膠奈米複合材料作為抗菌敷料

Abstract

我們開發了一種新穎超分子奈米銀水膠奈米複合材料可以有效地應用在抗菌傷口敷料上。我們設計是將超分子為模板，在超分子奈米纖維上的超分子具有許多羧酸(-COOH)和硫基(-SH)可提供銀離子的螯合位置。超分子奈米銀奈米複合材料是利用水溶液的方法製備。超分子結合銀離子可以提供銀離子作為還原反應的原料，藉由硼氫化鈉還原劑將其還原成超分子納米複合材料，此材料不需要額外添加任何保護劑就具有高度的穩定性及分散性。我們藉由光學圖像、掃描電子顯微鏡（SEM）、能量散佈分析儀（EDS）分析和紫外光-可見光譜等儀器來探討此材料的一些基本特性。此材料在抗菌試驗中展現出良好抗革蘭氏陽性菌和革蘭氏陰性菌的效果，並具有良好的生物相容性。最後，我們成功展示了一種新穎的超分子奈米銀水膠奈米複合材料具有良好的生物相容性和穩定性，可提供一種新穎的超分子奈米銀水膠應用在未來抗菌傷口敷料上。

Here, we have developed a novel supramolecular hydrogel–silver nanoparticles (AgNPs) nanocomposite as long term antibacterial wound dressings. The supramolecules are designed that they exhibits many carboxylic acid and thiol groups on the supramolecule nanofibers surface, which can offer as silver metal ion binding sites. The antibacterial nanocomposite was prepared by aqueous reduction method. The supramolecule-Ag ions offer silver metal ion was reduced by NaBH4 agent. These antibacterial nanocomposite does not require any external stabilizing agents with high monodispersity and stability. The nanocomposites were characterized by optical images, UV-vis spectra, Scanning electron microscope (SEM) images and Energy Dispersive Spectrometer (EDS) analysis. They have shown good antibacterial effect against both Gram-positive and Gram-negative bacteria and favorable biocompatibility to Hela cell. Finally, we have been demonstrated a novel supramolecular hydrogel–silver nanoparticles nanocomposites that employs the supramolecule for the development of functional supramolecule that have favorable biostability and capping agent, which offers a novel of supramolecular hydrogels of antibacterial wound dressings applications.