利用近紅外線光譜儀系統進行腦灌注壓評估

Abstract

對於臨床而言，在腦創傷後如何預防二次腦傷是十分重要的，而腦灌注壓是監測腦傷重要的指標之一，它與血液流入到腦部的多寡有關，並能夠間接反應腦是否缺血及缺氧。近年來，近紅外線光譜儀為一種非侵入式的檢測方式且可用來評估腦的氧合狀況及是否缺血，我們使用所提出的無線近紅外線光譜儀與市售的顱內壓以及平均動脈壓儀器來監測不同創傷力道下的老鼠腦部。隨著撞擊力道的增加來觀察腦灌注壓與近紅外線光譜儀參數之相關性，結果顯示腦灌注壓及近紅外線光譜儀之參數的改變量都會與創傷力道的增加而降低，除此之外，腦灌注壓改變量對於含氧血紅素、全血紅素、非含氧血紅素改變量的相關係數分別為0.73、0.6、0.36。因此，近紅外線光譜儀可以能以非侵入式的方式來評估相對腦部灌注壓的程度。

Prevention of secondary brain injury after Traumatic brain injury (TBI) is important in clinical. Cerebral perfusion pressure is associated with blood flow into the brain, and indirectly reflects the cerebral ischemia and oxygenation. Recently, near infrared spectroscopy (NIRS) have been developed and is available to access the cerebral ischemia and hypoxia non-invasively. In this study, we used proposed wireless NIRS system, and commercial intracranial pressure (ICP) and mean arterial pressure (MAP) devices to monitor rat’s brain in different impact strengths of trauma. With the increased impact strength, the relationship between CPP and NIRS parameters will be investigated. Results show that the ∆CPP and NIRS parameters were inversely proportional to the increased impact strengths, and the correlation coefficient between ∆CPP, and ∆[HbO2], ∆[HbT], and ∆[HbR] are 0.73, 0.6, and 0.36 respectively. Therefore, NIRS system is useful to assess the level of cerebral perfusion pressure non-invasively.