應用於術中脊髓神經電生理監測之微型標籤式磁刺激元件之研究

Abstract

本論文討論微型線圈應用於製作微型磁刺激器以應用於術中神經電生理訊號監測系統之可能性與其物理模型之建立及分析，並用商用微型線圈作為表準量測與分析的基礎，進而建立磁刺激器物理模型及相關的物理參數分析，以了解微縮化後的磁刺激器標籤化製程的可能性及其關鍵物理因素。此外也以平面螺旋電感及噴印技術製作的3D線圈做量測，於實驗中得知磁刺激器微型化後之線圈理想結構，是為有效產生單向高密度的電流之線性結構。透過噴印之平面導線於通入0.1安培1kHz之電流後，即可在距離該結構3mm處產生約18μV之感應電壓。此發現將可作為後續微磁刺激器系統之最佳化設計。

In the thesis the feasibility of micro-coil magnetic stimulator applied to intraoperative neurophysiological monitoring system has been investigated for the applications of intraoperative monitoring nerve system in terms of the analyses of the physical model with associated physical parameters of the stimulators. Commercial available solenoid coils are utilized first for the validation of the magnetic induction and the understanding of the associated physical model and related parameters for the development of miniaturized magnetic microstimulators. Planar spiral and inkjet printed 3D coils are then fabricated and characterized for the feasibility study and optimal design of microcoils for future magnetic microstimulation. Experimental results show that in idea coil structure in the miniaturized magnetic stimulator would be the one to generate high density current flow along one direction, i.e. a single straight line. With 0.1A, 1kHz sinusoid current input onto an inkjet printed line, ~18μV induced voltage can be measured at the location with the distance of 3mm away from it. The research finding will provide a guideline for the future design of magnetic micro-stimulation system.