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dc.contributor.authorChanda, Kaushiken_US
dc.contributor.authorKuo, Jarenen_US
dc.contributor.authorChen, Chih-Hauen_US
dc.contributor.authorSun, Chung-Mingen_US
dc.date.accessioned2014-12-08T15:09:56Z-
dc.date.available2014-12-08T15:09:56Z-
dc.date.issued2009-03-01en_US
dc.identifier.issn1520-4766en_US
dc.identifier.urihttp://dx.doi.org/10.1021/cc800137pen_US
dc.identifier.urihttp://hdl.handle.net/11536/7582-
dc.description.abstractFocused microwave irradiation has been applied to a multistep synthetic sequence of reactions designed to generate benzimidazolyl quinoxalinones using a soluble polymer support. They were obtained by the ipso-fluoro (S(N)Ar) displacement of the immobilized ortho-nitro fluoro benzimidazoles with chiral alpha amino esters under microwave irradiation. Intermediate chiral organic-polymer conjugates when subjected to neutral reduction underwent a spontaneous intramolecular ring closure. Cleavage of the polymer support, at room temperature, did not cause any significant racemization resulting in the generation of a chiral molecular library with two points of structural diversity.en_US
dc.language.isoen_USen_US
dc.titleEnantioselective Synthesis of Benzimidazolyl Quinoxalinones on Soluble Polymer Support Using Focused Microwave Irradiationen_US
dc.typeArticleen_US
dc.identifier.doi10.1021/cc800137pen_US
dc.identifier.journalJOURNAL OF COMBINATORIAL CHEMISTRYen_US
dc.citation.volume11en_US
dc.citation.issue2en_US
dc.citation.spage252en_US
dc.citation.epage260en_US
dc.contributor.department應用化學系zh_TW
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.identifier.wosnumberWOS:000264110800012-
dc.citation.woscount14-
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