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dc.contributor.authorLiu, Ting-Yuen_US
dc.contributor.authorLiu, Kun-Hoen_US
dc.contributor.authorLiu, Dean-Moen_US
dc.contributor.authorChen, San-Yuanen_US
dc.contributor.authorChen, I-Weien_US
dc.date.accessioned2014-12-08T15:09:58Z-
dc.date.available2014-12-08T15:09:58Z-
dc.date.issued2009-02-24en_US
dc.identifier.issn1616-301Xen_US
dc.identifier.urihttp://dx.doi.org/10.1002/adfm.200801304en_US
dc.identifier.urihttp://hdl.handle.net/11536/7615-
dc.description.abstractSelf-assembled nanocapsules containing a hydrophilic core and a crosslinked yet thermosensitive shell are successfully prepared using poly(ethylene-oxide) poly(propylene-oxide)-poly(ethylene-oxide) block copolymers, 4-nitrophenyl chloroformate, gelatin, and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide. The core is further rendered magnetic by incorporating iron oxide nanoparticles via internal precipitation to enable externally controlled actuation under magnetic induction. The spherical nanocapsules exhibit a hydrophilic-to-hydrophobic transition at a characteristic but tunable temperature reaching 40 degrees C, triggering a size contraction and shrinkage of the core. The core content experiences very little leakage at 25 degrees C, has a half life about 5 h at 45 degrees C, but bursts out within a few minutes under magnetic heating due to iron oxide coarsening and core/shell disruption. Such burst-like response may be utilized for controlled drug release as illustrated here using a model drug Vitamin B12.en_US
dc.language.isoen_USen_US
dc.titleTemperature-Sensitive Nanocapsules for Controlled Drug Release Caused by Magnetically Triggered Structural Disruptionen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/adfm.200801304en_US
dc.identifier.journalADVANCED FUNCTIONAL MATERIALSen_US
dc.citation.volume19en_US
dc.citation.issue4en_US
dc.citation.spage616en_US
dc.citation.epage623en_US
dc.contributor.department材料科學與工程學系zh_TW
dc.contributor.departmentDepartment of Materials Science and Engineeringen_US
dc.identifier.wosnumberWOS:000264275300013-
dc.citation.woscount63-
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