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dc.contributor.authorWu, Yao-Kuangen_US
dc.contributor.authorChen, Kuei-Tienen_US
dc.contributor.authorKuo, Yung-Binen_US
dc.contributor.authorHuang, Ya-Shuen_US
dc.contributor.authorChan, Err-Chengen_US
dc.date.accessioned2014-12-08T15:10:07Z-
dc.date.available2014-12-08T15:10:07Z-
dc.date.issued2009-01-18en_US
dc.identifier.issn0304-3835en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.canlet.2008.08.023en_US
dc.identifier.urihttp://hdl.handle.net/11536/7738-
dc.description.abstractin the present study, pleural effusions are the first time to be used as the specimens for detection of survivin expression in lung cancer patients. We demonstrated that by quantifying survivin expression with enzyme-linked immunosorbent assay (ELISA) in the 80 effusion samples exhibited a diagnostic power of 85% and 75% in sensitivity and specificity, respectively. A multivariate analysis with the Cox regression model revealed that both high survivin expression and cancer cells of stage IV were the indicators for poor prognosis of lung cancer. In conclusion, quantitative assay of survivin in pleural effusion could be useful both in diagnosis and prognosis for lung cancer. (C) 2008 Elsevier Ireland Ltd. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectSurvivin expressionen_US
dc.subjectPleural effusionen_US
dc.subjectSurvival rateen_US
dc.subjectPrognosisen_US
dc.subjectLung canceren_US
dc.titleQuantitative detection of survivin in malignant pleural effusion for the diagnosis and prognosis of lung canceren_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.canlet.2008.08.023en_US
dc.identifier.journalCANCER LETTERSen_US
dc.citation.volume273en_US
dc.citation.issue2en_US
dc.citation.spage331en_US
dc.citation.epage335en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
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