完整後設資料紀錄
DC 欄位語言
dc.contributor.authorChang, Wong-Jinen_US
dc.contributor.authorChanda, Kaushiken_US
dc.contributor.authorSun, Chung-Mingen_US
dc.date.accessioned2014-12-08T15:10:11Z-
dc.date.available2014-12-08T15:10:11Z-
dc.date.issued2009en_US
dc.identifier.issn0004-9425en_US
dc.identifier.urihttp://hdl.handle.net/11536/7777-
dc.identifier.urihttp://dx.doi.org/10.1071/CH08334en_US
dc.description.abstractStructural analogues of tadalafil that contain two diversity points have been synthesized from a soluble polymer support employing a Pictet-Spengler reaction using focussed microwave irradiation. Polymer-bound deprotected tryptophan reacts with various aldehydes to generate the tetrahydro-beta-carbolines on the support. Subsequently immobilized tetrahydro-beta-carboline underwent a highly efficient intramolecular N-heterocyclization in a traceless fashion from various in-situ generated alpha-alkyl and heteroalkyl amides in two steps to generate tetracyclic 2,5-diketopiperazines in high purity. All the compounds were isolated as cis and trans isomers with good yields.en_US
dc.language.isoen_USen_US
dc.titleMicrowave-Assisted Synthesis of Tetracyclic 2,5-Diketopiperazines on a Soluble Polymer Support: A Structural Analogue of Tadalafilen_US
dc.typeArticleen_US
dc.identifier.doi10.1071/CH08334en_US
dc.identifier.journalAUSTRALIAN JOURNAL OF CHEMISTRYen_US
dc.citation.volume62en_US
dc.citation.issue1en_US
dc.citation.spage42en_US
dc.citation.epage50en_US
dc.contributor.department應用化學系zh_TW
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.identifier.wosnumberWOS:000262656200005-
dc.citation.woscount2-
顯示於類別:期刊論文