標題: | Detection of gold nanoparticles using an immunoglobulin-coated piezoelectric sensor |
作者: | Chen, Yu-Shiun Hung, Yao-Ching Chen, Kaochao Huang, Guewha Steven 材料科學與工程學系 材料科學與工程學系奈米科技碩博班 Department of Materials Science and Engineering Graduate Program of Nanotechnology , Department of Materials Science and Engineering |
公開日期: | 10-十二月-2008 |
摘要: | Since the existence of nanoparticles in our environment has already attracted considerable attention due to their possible toxic impact on biological systems, the field detection of nanoparticles is becoming a technology that will be much in need. We have constructed a piezoelectric sensor with an antibody-coated electrode. The antiserum can bind gold nanoparticles with a high degree of selectivity and sensitivity. The biosensor thus constructed can detect 4, 5, or 6 nm gold nanoparticles (GNPs) depending on the coated antiserum. The sensitivity for the detection of 5 nm GNPs was 10.3 +/- 0.9 ng Hz(-1), with the low limit of detection at 5.5 ng. A quartz crystal microbalance (QCM) sensor was capable of detecting GNPs and other types of nanoparticle, such as ZnO, or Fe(3)O(4). The current study provides, for the first time, a platform for detecting nanoparticles in a convenient, economical manner. |
URI: | http://dx.doi.org/10.1088/0957-4484/19/49/495502 http://hdl.handle.net/11536/8037 |
ISSN: | 0957-4484 |
DOI: | 10.1088/0957-4484/19/49/495502 |
期刊: | NANOTECHNOLOGY |
Volume: | 19 |
Issue: | 49 |
結束頁: | |
顯示於類別: | 期刊論文 |