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dc.contributor.authorWu, Li-Chingen_US
dc.contributor.authorHorng, Jorng-Tzongen_US
dc.contributor.authorHuang, Hsien-Daen_US
dc.contributor.authorChen, Wei-Longen_US
dc.date.accessioned2014-12-08T15:10:44Z-
dc.date.available2014-12-08T15:10:44Z-
dc.date.issued2008-11-01en_US
dc.identifier.issn1089-7771en_US
dc.identifier.urihttp://dx.doi.org/10.1109/TITB.2008.896871en_US
dc.identifier.urihttp://hdl.handle.net/11536/8210-
dc.description.abstractRecently, the H5N1 virus has had an increasingly important impact on human life. This is because more and more people are becoming infected with this virus, and the possibility of a serious pandemic with human to human transmission is looming. This might occur if the genome of this influenza virus mutates either by antigenic drift or by antigenic shift, especially if there is a mutation of the hemagglutinin (HA) glycoprotein. The HA is the surface glycoprotein, and it binds to sialic acid of the host cell surface receptor. Thus, the combination of HA and sialic acid are central to whether influenza virus infects humans. In this study, we selected 497 HA protein sequences from the National Center for Biotechnology Information (NCBI) Influenza Resource database, and used a decision tree method to identify discriminative amino acids in the HA protein sequences that may possibly influence the binding of HA to sialic acid. Four such amino acid positions at 54, 55, 241, and 281 were identified and these may play an important role in infection by H5N1 influenza virus.en_US
dc.language.isoen_USen_US
dc.subjectDecision treeen_US
dc.subjecthemagglutinin (HA)en_US
dc.subjectinfluenza A H5N1 virusen_US
dc.titleIdentifying Discriminative Amino Acids Within the Hemagglutinin of Human Influenza A H5N1 Virus Using a Decision Treeen_US
dc.typeArticleen_US
dc.identifier.doi10.1109/TITB.2008.896871en_US
dc.identifier.journalIEEE TRANSACTIONS ON INFORMATION TECHNOLOGY IN BIOMEDICINEen_US
dc.citation.volume12en_US
dc.citation.issue6en_US
dc.citation.spage689en_US
dc.citation.epage695en_US
dc.contributor.department生物資訊及系統生物研究所zh_TW
dc.contributor.departmentInstitude of Bioinformatics and Systems Biologyen_US
dc.identifier.wosnumberWOS:000260956800001-
dc.citation.woscount4-
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