標題: | Integrated multiple multi-photon imaging and Raman spectroscopy for characterizing structure-constituent correlation of tissues |
作者: | Jhan, Jhen-Wei Chang, Wei-Tien Chen, Hung-Che Lee, Yu-Tsung Wu, Ming-Fang Chen, Chung-Hsuan Liau, Ian 應用化學系 應用化學系分子科學碩博班 Department of Applied Chemistry Institute of Molecular science |
公開日期: | 13-十月-2008 |
摘要: | Histopathological imaging of tissues often requires extensive sample preparation including fixation and staining in order to highlight characteristic alterations associated with diseases. Herein, we report an integrated spectro-microscopy approach based on a combination of multimodal multi-photon imaging and Raman micro-spectroscopy and demonstrate label-free characterization of the structure-constituent correlation of porcine skin. The multi-modal imaging allows the visualization of dermatological features whereas Raman micro-spectroscopy enables the identification of their 'molecular fingerprints'. By obtaining both structural and molecular-level information of tissue constituents, this integrated approach can offer new insight into the patho-physiological status of tissues. (c) 2008 Optical Society of America |
URI: | http://dx.doi.org/10.1364/OE.16.016431 http://hdl.handle.net/11536/8253 |
ISSN: | 1094-4087 |
DOI: | 10.1364/OE.16.016431 |
期刊: | OPTICS EXPRESS |
Volume: | 16 |
Issue: | 21 |
起始頁: | 16431 |
結束頁: | 16441 |
顯示於類別: | 期刊論文 |