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dc.contributor.authorZhang, Xiaomingen_US
dc.contributor.authorZhao, Hongweien_US
dc.contributor.authorGao, Shangen_US
dc.contributor.authorWang, Wei-Chien_US
dc.contributor.authorKatiyar-Agarwal, Surekhaen_US
dc.contributor.authorHuang, Hsien-Daen_US
dc.contributor.authorRaikhel, Natashaen_US
dc.contributor.authorJin, Hailingen_US
dc.date.accessioned2014-12-08T15:11:34Z-
dc.date.available2014-12-08T15:11:34Z-
dc.date.issued2011-05-06en_US
dc.identifier.issn1097-2765en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.molcel.2011.04.010en_US
dc.identifier.urihttp://hdl.handle.net/11536/8875-
dc.description.abstractArgonaute (AGO) proteins are critical components of RNA silencing pathways that bind small RNAs and mediate gene silencing at their target sites. We found that Arabidopsis AGO2 is highly induced by the bacterial pathogen Pseudomonas syringae pv. tomato (Pst). Further genetic analysis demonstrated that AGO2 functions in antibacterial immunity. One abundant species of AGO2-bound small RNA is miR393b*, which targets a Golgi-localized SNARE gene, MEMB12. Pst infection downregulates MEMB12 in a miR393b*-dependent manner. Loss of function of MEMB12, but not SYP61, another intracellular SNARE, leads to increased exocytosis of an antimicrobial pathogenesis-related protein, PR1. Overexpression of miR393b* resembles memb12 mutant in resistance responses. Thus, AGO2 functions in antibacterial immunity by binding miR393b* to modulate exocytosis of antimicrobial PR proteins via MEMB12. Since miR393 also contributes to antibacterial responses, miR393*/miR393 represent an example of a miRNA*/miRNA pair that functions in immunity through two distinct AGOs: miR393* through AGO2 and miR393 through AGO1.en_US
dc.language.isoen_USen_US
dc.titleArabidopsis Argonaute 2 Regulates Innate Immunity via miRNA393*-Mediated Silencing of a Golgi-Localized SNARE Gene, MEMB12en_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.molcel.2011.04.010en_US
dc.identifier.journalMOLECULAR CELLen_US
dc.citation.volume42en_US
dc.citation.issue3en_US
dc.citation.spage356en_US
dc.citation.epage366en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.department生物資訊及系統生物研究所zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentInstitude of Bioinformatics and Systems Biologyen_US
dc.identifier.wosnumberWOS:000290465900011-
dc.citation.woscount83-
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