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dc.contributor.author吳淑褓en_US
dc.contributor.authorWU SHU-PAOen_US
dc.date.accessioned2014-12-13T10:41:29Z-
dc.date.available2014-12-13T10:41:29Z-
dc.date.issued2012en_US
dc.identifier.govdocNSC101-2113-M009-016-MY2zh_TW
dc.identifier.urihttp://hdl.handle.net/11536/98477-
dc.identifier.urihttps://www.grb.gov.tw/search/planDetail?id=2586520&docId=390215en_US
dc.description.abstract這個計畫主要是針對三種離子:Fe(III)、Hg(II)及Cu(II),分別設計及合成適合的化學偵測分子,用來偵測這些離子,並評估於cell imaging的應用。分別以pyrene,rhodamine及BODIPY當成訊號來源,分別接上螯合基來進行金屬離子的辨識。所設計的分子,分別測試其對於個別金屬離子的選擇性,所選用金屬離子包括Ag(I), Ca(II), Cd(II), Co(II), Cu(II), Fe(II), Fe(III), Hg(II), Mg(II), Mn(II), Ni(II), Pb(II), Zn(II)。主要觀察金屬離子對化學偵測分子的鍵結,是否造成吸收波長或是螢光強度的改變,而產生辨識的效果。有關所設計化學偵測分子的評估,包括金屬離子的選擇性(以UV-Vis 及螢光光譜判定)、金屬離子的鍵結常數(binding affinity constant)、pH對鍵結的影響(pH dependent binding study)。所設計的金屬離子化學偵測分子,測試後發現屬於螢光改變的偵測分子,將進行細胞實驗,來評估是否能夠在細胞中偵測金屬離子。zh_TW
dc.description.abstractThe project is focused on the development of Fe(III), Hg(II) and Cu(II) chemosensors. The chemosensors based on pyrene, rhodamine and BODIPY are designed for Fe(III), Hg(II), Cu(II) sensing. Metal ions such as Ag(I), Ca(II), Cd(II), Co(II), Cu(II), Fe(II), Fe(III), Hg(II), Mg(II), Mn(II), Ni(II), Pb(II), Zn(II) are going to test the selectivity of chemosensors. The detailed studies include metal ion selectivity studied by UV-Vis and fluorescence spectra, binding affinity constants and pH dependent binding study. Chemosensors which can detect Fe(III) (or Hg(II), Cu(II)) as a fluorescent turn-on process are going to test their Fe(III) (or Hg(II), Cu(II)) detecting ability in living cells.en_US
dc.description.sponsorship行政院國家科學委員會zh_TW
dc.language.isozh_TWen_US
dc.subject三價鐵離子zh_TW
dc.subject二價汞離子zh_TW
dc.subject二價銅離子zh_TW
dc.subject化學偵測分子zh_TW
dc.subjectpyrenezh_TW
dc.subjectrhodaminezh_TW
dc.subjectBODIPYzh_TW
dc.subjectFe(III)en_US
dc.subjectHg(II)en_US
dc.subjectCu(II)en_US
dc.subjectchemosensorsen_US
dc.subjectpyreneen_US
dc.subjectrhodamineen_US
dc.subjectBODIPYen_US
dc.titleFe(III)、Hg(II)及Cu(II)化學偵測分子設計、合成及cell imaging的應用zh_TW
dc.titleDesign and Synthesis of Fe(Iii), Hg(Ii) and Cu(Ii) Chemosensors and Their Applications to Living Cell Imagingen_US
dc.typePlanen_US
dc.contributor.department國立交通大學應用化學系(所)zh_TW
Appears in Collections:Research Plans