标题: | 超分子水凝胶在抗癌奈米药物之应用 Application of Supramolecular Hydrogel in Anticancer Nanomedicine |
作者: | 林欣杰 Lin Hsin-Chieh 国立交通大学材料科学与工程学系(所) |
关键字: | 水凝胶;自组装;超分子;奈米药物;酵素;Hydrogel;self-assembly;supramolecular;nanomedicine;enzyme |
公开日期: | 2011 |
摘要: | 随着奈米科学与奈米科技的新知快速进展而产生了新的研究領域,这个領域可以 提供许多机会研发新的药物來治療癌症以及改善人類的生活品质。到目前为止, 以奈米科技为中心的研究領域在生医方向上已经有一些明显的成果,例如在药物 输送载体以及新的治療方法方面。因此,我们希望更进一步的发展利用酵素催化 使小分子可以在细胞内自组装产生含药物的奈米纤维结构。我们提出利用含抗癌 药物水凝胶因子在细胞内自组装來对抗多重抗药性以及增加局部性药物浓度來 提高与目标物的作用力,这个新方法可能提供在臨床上可以用來处理有抗药性癌 症的解决方法。此外,研究利用酵素來产生奈米纤维是一个新的方法來发展抗癌 奈米药物。本计画将利用酵素使含抗癌药物的超分子水凝胶产生自组装奈米药物 來治療癌症,我们计画达成三个主要目标,而透过这样的研究将可以提供一个合 邏辑的方式让我们达到最后目的-发展新的奈米药物。第一个目标将致力于发展 含萤光团的胜肽分子來产生新的萤光超分子水凝胶。第二个目标将整合抗癌药物 到可自组装的萤光超分子水凝胶分子结构中以及研究含抗癌药物的奈米纤维的 细胞反应。第三个目标将尝试把光敏剂合并到自组装奈米纤维中以及评估在癌细 胞内光动力治療效果。我们相信本计画的成功将会开启一个发展抗癌奈米药物的 全新方法 The rapid growth of new knowledge in nanoscience and nanotechnology is extending new research frontiers and offering exceptional opportunities of creating new generation of diagnostics and therapeutics to treat cancer and improve the quality of human life. The considerable research interests in the area have already made significant progresses, such like drug delivery carriers and new treatment protocols. Therefore, we wish to further develop enzyme catalysis that triggers the self-assembly of small molecules to form drug-decorated nanofibers inside cancer cells. We propose that intracellular self-assembly of the anticancer drug molecules will overcome multidrug resistance (MDR) by avoiding the efflux pumps and increasing the local concentration of drugs for enhance binding to the targets and may offer a new clinical solution for the treatment of drug resistance cancers. Besides, the investigation of enzymatic formation of molecular nanofibers is a new approach for developing anticancer nanomedicine. The present work will focus on the usage of self-assembly and enzyme catalysis to create molecular nanofibers by supramolecular hydrogelators as novel nanomedicines for anticancer therapy. Three specific aims will be investigated and that will provide a logical approach for us to reach the final goal – development of new nanomedicine. The first aim focuses on the development of fluorophore-capped peptides as new supramolecular hydroglators. The second aim is to combine anticancer drug into the structure of hydrogelator and study the effects of the drug-containing nanofibers formed inside cells for inducing cell death. The third aim deals with the photosensitizer-containing nanofibers for evaluating their photodynamic functions, and effectiveness inside cells. We believe the success of the proposed research will open up a new strategy for the development of anticancer nanomedicines. |
官方说明文件#: | NSC100-2113-M009-015-MY2 |
URI: | http://hdl.handle.net/11536/99287 https://www.grb.gov.tw/search/planDetail?id=2373883&docId=375930 |
显示于类别: | Research Plans |