A synthetic complement C1q-like peptide selectively interacts with immune complexes
| dc.citation.epage | 1123 | en_US |
| dc.citation.issue | 12 | en_US |
| dc.citation.spage | 1119 | en_US |
| dc.citation.volume | 20 | en_US |
| dc.citation.woscount | 0 | |
| dc.contributor.author | Chan, EC | en_US |
| dc.contributor.author | Pan, MZ | en_US |
| dc.contributor.author | Chang, CA | en_US |
| dc.contributor.author | Wu, TZ | en_US |
| dc.contributor.author | Kuo, YB | en_US |
| dc.contributor.department | 生物科技學系 | zh_TW |
| dc.contributor.department | Department of Biological Science and Technology | en_US |
| dc.date.accessioned | 2014-12-08T15:47:22Z | |
| dc.date.available | 2014-12-08T15:47:22Z | |
| dc.date.issued | 1998-12-01 | en_US |
| dc.description.abstract | A water-soluble peptide possessing an immune complex selective affinity was synthesized and its primary structure established as: Leu-Glu-Gln-Gly-Glu-Asn-Val-Phe-Leu-Gln-Ala-Thr-Ser-Asp-Asp-Cys. This peptide, designated as C1q-like peptide (CLP), represents a possible immune complex binding epitope of complement C1q. CLP has a hydrophilicity value of 0.21. At 0.5 mu M, it inhibited by 50% natural human C1q from binding to horseradish peroxidase-rabbit anti-peroxidase immune complex. CLP failed to inhibit Staphylococcus aureus protein A from binding monomeric IgG. When coated to a microplate, CLP showed selective binding to the immune complex, and could be used for application in immunochemical detection of immune complex. | en_US |
| dc.identifier.doi | 10.1023/A:1005368118207 | en_US |
| dc.identifier.issn | 0141-5492 | en_US |
| dc.identifier.journal | BIOTECHNOLOGY LETTERS | en_US |
| dc.identifier.uri | http://dx.doi.org/10.1023/A:1005368118207 | en_US |
| dc.identifier.uri | https://ir.lib.nycu.edu.tw/handle/11536/31751 | |
| dc.identifier.wosnumber | WOS:000078348200006 | |
| dc.language.iso | en_US | en_US |
| dc.subject | human complement C1q-like peptide | en_US |
| dc.subject | immune complex | en_US |
| dc.subject | hydrophilicity | en_US |
| dc.title | A synthetic complement C1q-like peptide selectively interacts with immune complexes | en_US |
| dc.type | Article | en_US |