Activation of rabbit TLR9 by different CpG-ODN optimized for mouse and human TLR9
| dc.citation.epage | 443 | en_US |
| dc.citation.issue | 5 | en_US |
| dc.citation.volume | 35 | en_US |
| dc.citation.woscount | 4 | |
| dc.contributor.author | Liu, Jin | en_US |
| dc.contributor.author | Xu, Congfeng | en_US |
| dc.contributor.author | Liu, Yi-Ling | en_US |
| dc.contributor.author | Matsuo, Hanako | en_US |
| dc.contributor.author | Hsieh, Rebecca Pe-Feng | en_US |
| dc.contributor.author | Lo, Jeng-Fan | en_US |
| dc.contributor.author | Tseng, Ping-Hui | en_US |
| dc.contributor.author | Yuan, Chiun-Jye | en_US |
| dc.contributor.author | Luo, Yunping | en_US |
| dc.contributor.author | Xiang, Rong | en_US |
| dc.contributor.author | Chuang, Tsung-Hsien | en_US |
| dc.contributor.department | 生物科技學系 | zh_TW |
| dc.contributor.department | Department of Biological Science and Technology | en_US |
| dc.date.accessioned | 2014-12-08T15:24:03Z | |
| dc.date.available | 2014-12-08T15:24:03Z | |
| dc.date.issued | 2012-09-01 | en_US |
| dc.description.abstract | "Synthetic CpG-oligodeoxynucleotides (CpG-ODN) are potent adjuvants that accelerate and boost antigen-specific immune responses. Toll-like receptor 9 (TLR9) is the cellular receptor for these CpG-ODN. Previous studies have shown species-specific activation of mouse TLR9 (mTLR9) and human TLR9 (hTLR9) by their optimized CpG-ODN. The interaction between rabbit TLR9 (rabTLR9) and CpG-ODN, however, has not been previously investigated. Here, we cloned and characterized rabTLR9 and comparatively investigated the activation of the rabbit, mouse, and human TLR9 by CpG-ODN. The complete open reading frame of rabTLR9 encodes 1028 amino acid residues, which share 70.6% and 75.5% of the identities of mTLR9 and hTLR9, respectively. Rabbit TLR9 is preferentially expressed in immune cells rich tissues, and is localized in intracellular vesicles. While mTLR9 and hTLR9 displayed species-specific recognition of their optimized CpG-ODN, rabbit TLR9 was activated by these CpG-ODN without any preference. This result suggests that rabTLR9 has a broader ligand-recognition profile than mouse and human TLR9. (C) 2012 Elsevier Ltd. All rights reserved." | en_US |
| dc.identifier.issn | 0147-9571 | en_US |
| dc.identifier.journal | COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES | en_US |
| dc.identifier.uri | https://ir.lib.nycu.edu.tw/handle/11536/16716 | |
| dc.identifier.wosnumber | WOS:000307616000005 | |
| dc.language.iso | en_US | en_US |
| dc.subject | Immune adjuvant | en_US |
| dc.subject | Pattern recognition receptor | en_US |
| dc.subject | Toll-like receptor 9 | en_US |
| dc.subject | CpG-ODN | en_US |
| dc.subject | Nuclear factor-kappa B | en_US |
| dc.title | Activation of rabbit TLR9 by different CpG-ODN optimized for mouse and human TLR9 | en_US |
| dc.type | Article | en_US |