Sequential one-pot enzymatic synthesis of oligo-N-acetyllactosamine and its multi-sialylated extensions
| dc.citation.epage | 5789 | en_US |
| dc.citation.issue | 43 | en_US |
| dc.citation.spage | 5786 | en_US |
| dc.citation.volume | 50 | en_US |
| dc.citation.woscount | 1 | |
| dc.contributor.author | Chien, Wei-Ting | en_US |
| dc.contributor.author | Liang, Chien-Fu | en_US |
| dc.contributor.author | Yu, Ching-Ching | en_US |
| dc.contributor.author | Lin, Chien-Hung | en_US |
| dc.contributor.author | Li, Si-Peng | en_US |
| dc.contributor.author | Primadona, Indah | en_US |
| dc.contributor.author | Chen, Yu-Ju | en_US |
| dc.contributor.author | Mong, Kwok Kong T. | en_US |
| dc.contributor.author | Lin, Chun-Cheng | en_US |
| dc.contributor.department | 應用化學系 | zh_TW |
| dc.contributor.department | Department of Applied Chemistry | en_US |
| dc.date.accessioned | 2014-12-08T15:35:56Z | |
| dc.date.available | 2014-12-08T15:35:56Z | |
| dc.date.issued | 2014 | en_US |
| dc.description.abstract | A simple and efficient protocol for the preparative-scale synthesis of various lengths of oligo-N-acetyllactosamine (oligo-LacNAc) and its multi-sialylated extensions is described. The strategy utilizes one thermophilic bacterial thymidylyltransferase (RmlA) coupled with corresponding sugar-1-phosphate kinases to generate two uridine diphosphate sugars, UDP-galactose and UDP-N-acetylglucosamine. By incorporating glycosyltransferases, oligo-LacNAcs and their sialylated analogs were synthesized. | en_US |
| dc.identifier.doi | 10.1039/c4cc01227e | en_US |
| dc.identifier.issn | 1359-7345 | en_US |
| dc.identifier.journal | CHEMICAL COMMUNICATIONS | en_US |
| dc.identifier.uri | http://dx.doi.org/10.1039/c4cc01227e | en_US |
| dc.identifier.uri | https://ir.lib.nycu.edu.tw/handle/11536/24312 | |
| dc.identifier.wosnumber | WOS:000335554300028 | |
| dc.language.iso | en_US | en_US |
| dc.title | Sequential one-pot enzymatic synthesis of oligo-N-acetyllactosamine and its multi-sialylated extensions | en_US |
| dc.type | Article | en_US |