Synthesis of acylguanidine zanamivir derivatives as neuraminidase inhibitors and the evaluation of their bio-activities
| dc.citation.epage | 3948 | en_US |
| dc.citation.issue | 24 | en_US |
| dc.citation.spage | 3943 | en_US |
| dc.citation.volume | 11 | en_US |
| dc.citation.woscount | 8 | |
| dc.contributor.author | Lin, Chien-Hung | en_US |
| dc.contributor.author | Chang, Tsung-Che | en_US |
| dc.contributor.author | Das, Anindya | en_US |
| dc.contributor.author | Fang, Ming-Yu | en_US |
| dc.contributor.author | Hung, Hui-Chen | en_US |
| dc.contributor.author | Hsu, Kai-Cheng | en_US |
| dc.contributor.author | Yang, Jinn-Moon | en_US |
| dc.contributor.author | von Itzstein, Mark | en_US |
| dc.contributor.author | Mong, Kwok Kong T. | en_US |
| dc.contributor.author | Hsu, Tsu-An | en_US |
| dc.contributor.author | Lin, Chun-Cheng | en_US |
| dc.contributor.department | 生物科技學系 | zh_TW |
| dc.contributor.department | 應用化學系 | zh_TW |
| dc.contributor.department | Department of Biological Science and Technology | en_US |
| dc.contributor.department | Department of Applied Chemistry | en_US |
| dc.date.accessioned | 2014-12-08T15:31:44Z | |
| dc.date.available | 2014-12-08T15:31:44Z | |
| dc.date.issued | 2013 | en_US |
| dc.description.abstract | A series of acylguanidine-modified zanamivir analogs were synthesized and their inhibitory activities against the NAs of avian influenza viruses (H1N1 and H3N2) were evaluated. In particular, zanamivir derivative 3j, with a hydrophobic naphthalene substituent, exhibits the best inhibitory activity against group-1 NA with an IC50 of 20 nM. | en_US |
| dc.identifier.doi | 10.1039/c3ob40624e | en_US |
| dc.identifier.issn | 1477-0520 | en_US |
| dc.identifier.journal | ORGANIC & BIOMOLECULAR CHEMISTRY | en_US |
| dc.identifier.uri | http://dx.doi.org/10.1039/c3ob40624e | en_US |
| dc.identifier.uri | https://ir.lib.nycu.edu.tw/handle/11536/22456 | |
| dc.identifier.wosnumber | WOS:000319670100002 | |
| dc.language.iso | en_US | en_US |
| dc.title | Synthesis of acylguanidine zanamivir derivatives as neuraminidase inhibitors and the evaluation of their bio-activities | en_US |
| dc.type | Article | en_US |