A switch-on MRI contrast agent for noninvasive visualization of methylmercury
| dc.citation.epage | 12035 | en_US |
| dc.citation.issue | 60 | en_US |
| dc.citation.spage | 12032 | en_US |
| dc.citation.volume | 51 | en_US |
| dc.citation.woscount | 0 | en_US |
| dc.contributor.author | Singh, Gyan | en_US |
| dc.contributor.author | Hsu, Kuang-Mei | en_US |
| dc.contributor.author | Chen, Yu-Jen | en_US |
| dc.contributor.author | Wu, Shou-Cheng | en_US |
| dc.contributor.author | Chen, Chiao-Yun | en_US |
| dc.contributor.author | Wang, Yun-Ming | en_US |
| dc.contributor.department | 生物科技學系 | zh_TW |
| dc.contributor.department | Department of Biological Science and Technology | en_US |
| dc.date.accessioned | 2015-12-02T02:59:22Z | |
| dc.date.available | 2015-12-02T02:59:22Z | |
| dc.date.issued | 2015-01-01 | en_US |
| dc.description.abstract | This communication presents the first Gd(III)-based T-1 MRI contrast agent, o-MeHgGad, for noninvasive visualization of CH3Hg+. o-MeHgGad showed a relaxivity enhancement of 62% in the presence of 1 equiv. of CH3Hg+. Moreover, a noticeable contrast enhancement was recorded in the liver, kidney, and intestine of mice exposed to CH3Hg+. Thus, the newly designed contrast agent has the potential to be used for in vivo bio-imaging of CH3Hg+ and could be useful for biomedical applications. | en_US |
| dc.identifier.doi | 10.1039/c5cc01723h | en_US |
| dc.identifier.issn | 1359-7345 | en_US |
| dc.identifier.journal | CHEMICAL COMMUNICATIONS | en_US |
| dc.identifier.uri | http://dx.doi.org/10.1039/c5cc01723h | en_US |
| dc.identifier.uri | https://ir.lib.nycu.edu.tw/handle/11536/128106 | |
| dc.identifier.wosnumber | WOS:000357951400022 | en_US |
| dc.language.iso | en_US | en_US |
| dc.title | A switch-on MRI contrast agent for noninvasive visualization of methylmercury | en_US |
| dc.type | Article | en_US |
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