Design and synthesis of activity probes for glycosidases
| dc.citation.epage | 3610 | en_US |
| dc.citation.issue | 21 | en_US |
| dc.citation.spage | 3607 | en_US |
| dc.citation.volume | 4 | en_US |
| dc.citation.woscount | 51 | |
| dc.contributor.author | Tsai, CS | en_US |
| dc.contributor.author | Li, YK | en_US |
| dc.contributor.author | Lo, LC | en_US |
| dc.contributor.department | 應用化學系 | zh_TW |
| dc.contributor.department | Department of Applied Chemistry | en_US |
| dc.date.accessioned | 2014-12-08T15:41:49Z | |
| dc.date.available | 2014-12-08T15:41:49Z | |
| dc.date.issued | 2002-10-17 | en_US |
| dc.description.abstract | [GRAPHICS] A new synthetic route was developed for the preparation of activity probe 1 for beta-glucosidase in this study. The key glycosidation step begins with benzyl p-hydroxyphenylacetate. Benzylic functionalization for the construction of the trapping device was achieved at later stages. Probe 1 was shown to be able to label the target enzyme. This cassette-like design offers great flexibility for future alterations. It would allow the synthetic scheme to expand to other glycosidase probes with different linker/reporter combinations. | en_US |
| dc.identifier.doi | 10.1021/ol0265315 | en_US |
| dc.identifier.issn | 1523-7060 | en_US |
| dc.identifier.journal | ORGANIC LETTERS | en_US |
| dc.identifier.uri | http://dx.doi.org/10.1021/ol0265315 | en_US |
| dc.identifier.uri | https://ir.lib.nycu.edu.tw/handle/11536/28446 | |
| dc.identifier.wosnumber | WOS:000178522700015 | |
| dc.language.iso | en_US | en_US |
| dc.title | Design and synthesis of activity probes for glycosidases | en_US |
| dc.type | Article | en_US |