Design and Synthesis of New Biprivileged Molecular Scaffolds: Indolo-Fused Benzodiazepinyl/quinoxalinyl benzimidazoles
| dc.citation.epage | 1684 | en_US |
| dc.citation.issue | 7 | en_US |
| dc.citation.volume | 7 | en_US |
| dc.citation.woscount | 4 | |
| dc.contributor.author | Barve, Indrajeet J. | en_US |
| dc.contributor.author | Chen, Chan-Yu | en_US |
| dc.contributor.author | Salunke, Deepak B. | en_US |
| dc.contributor.author | Chung, Wen-Sheng | en_US |
| dc.contributor.author | Sun, Chung-Ming | en_US |
| dc.contributor.department | 應用化學系 | zh_TW |
| dc.contributor.department | Department of Applied Chemistry | en_US |
| dc.date.accessioned | 2014-12-08T15:23:37Z | |
| dc.date.available | 2014-12-08T15:23:37Z | |
| dc.date.issued | 2012-06-01 | en_US |
| dc.description.abstract | The present article describes the design and synthesis of new biprivileged molecular scaffolds with diverse structural features. Commercially available, simple heterocyclic building blocks such as 4-fluoro-3-nitrobenzoic acid, 2-chloro-3-nitrobenzoic acid, and indoline were utilized for the synthesis of the novel heterocycles. PictetSpengler-type condensation was used as a key step to construct tetracyclic indolo-benzodiazepines and indolo-quinoxalines linked with substituted benzimidazoles. Analysis of single crystals of representative compounds showed that these molecular skeletons have the potential to present various substituents with distinct three-dimensional orientations. | en_US |
| dc.identifier.issn | 1861-4728 | en_US |
| dc.identifier.journal | CHEMISTRY-AN ASIAN JOURNAL | en_US |
| dc.identifier.uri | https://ir.lib.nycu.edu.tw/handle/11536/16516 | |
| dc.identifier.wosnumber | WOS:000305239500032 | |
| dc.language.iso | en_US | en_US |
| dc.subject | drug discovery | en_US |
| dc.subject | heterocycles | en_US |
| dc.subject | Pictet-Spengler-type reactions | en_US |
| dc.subject | privileged structures | en_US |
| dc.subject | synthesis design | en_US |
| dc.title | Design and Synthesis of New Biprivileged Molecular Scaffolds: Indolo-Fused Benzodiazepinyl/quinoxalinyl benzimidazoles | en_US |
| dc.type | Article | en_US |