A synthetic approach to tacamonine. Access to 3-epitacamonine and 14-epitacamonine

Abstract

3-Epitacamonine and 14-epitacamonine have been synthesized starting from the dinitrile 3. The synthetic route was designed on the basis of symmetric considerations which emphasized the establishment of the relative configuration in two of the three stereocenters. (C) 2001 Elsevier Science Ltd. All rights reserved.