Divergent Synthesis of Unsymmetrical Annulated Biheterocyclic Compound Libraries: Benzimidazole Linked Indolo-benzodiazepines/quinoxaline
| dc.citation.epage | 398 | en_US |
| dc.citation.issue | 4 | en_US |
| dc.citation.spage | 391 | en_US |
| dc.citation.volume | 13 | en_US |
| dc.citation.woscount | 11 | |
| dc.contributor.author | Chen, Li-Hsun | en_US |
| dc.contributor.author | Chang, Chia-Mao | en_US |
| dc.contributor.author | Salunke, Deepak B. | en_US |
| dc.contributor.author | Sun, Chung-Ming | en_US |
| dc.contributor.department | 應用化學系 | zh_TW |
| dc.contributor.department | Department of Applied Chemistry | en_US |
| dc.date.accessioned | 2014-12-08T15:30:45Z | |
| dc.date.available | 2014-12-08T15:30:45Z | |
| dc.date.issued | 2011-07-01 | en_US |
| dc.description.abstract | Diversity-oriented synthesis of novel benzimidazole linked indolo-benzodiazepine/quinoxaline ring systems using poly(ethylene glycol) as soluble polymer support is described. Corrunercially available 4-fluoro-3-nitrobenzoic acid and indoline were utilized for the construction of these annulated biheterocyclic compound libraries having multiple privileged structures with three-point structural diversity. A reagent based diversification approach coupled with the Pictet-Spengler-type condensation was used to construct the tetracydic indolo-benzodiazepines/quinoxalines on substituted benzimidazoles. | en_US |
| dc.identifier.doi | 10.1021/co200022u | en_US |
| dc.identifier.issn | 2156-8952 | en_US |
| dc.identifier.journal | ACS COMBINATORIAL SCIENCE | en_US |
| dc.identifier.uri | http://dx.doi.org/10.1021/co200022u | en_US |
| dc.identifier.uri | https://ir.lib.nycu.edu.tw/handle/11536/21969 | |
| dc.identifier.wosnumber | WOS:000292617500007 | |
| dc.language.iso | en_US | en_US |
| dc.subject | indolo-benzodiazepines/quinoxalines | en_US |
| dc.subject | Pictet-Spengler | en_US |
| dc.subject | diversity-oriented synthesis | en_US |
| dc.subject | PEG | en_US |
| dc.title | Divergent Synthesis of Unsymmetrical Annulated Biheterocyclic Compound Libraries: Benzimidazole Linked Indolo-benzodiazepines/quinoxaline | en_US |
| dc.type | Article | en_US |