Mutation of isoleucine 705 of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae affects lanosterol's C/D-ring cyclization and 17 alpha/beta-exocyclic side chain stereochemistry
| dc.citation.epage | 1097 | en_US |
| dc.citation.issue | 4 | en_US |
| dc.citation.spage | 1092 | en_US |
| dc.citation.volume | 9 | en_US |
| dc.citation.woscount | 6 | |
| dc.contributor.author | Wu, Tung-Kung | en_US |
| dc.contributor.author | Chang, Yi-Chun | en_US |
| dc.contributor.author | Liu, Yuan-Ting | en_US |
| dc.contributor.author | Chang, Cheng-Hsiang | en_US |
| dc.contributor.author | Wen, Hao-Yu | en_US |
| dc.contributor.author | Li, Wen-Hsuan | en_US |
| dc.contributor.author | Shie, Wen-Shiang | en_US |
| dc.contributor.department | 生物科技學系 | zh_TW |
| dc.contributor.department | Department of Biological Science and Technology | en_US |
| dc.date.accessioned | 2014-12-08T15:38:03Z | |
| dc.date.available | 2014-12-08T15:38:03Z | |
| dc.date.issued | 2011 | en_US |
| dc.description.abstract | Site-saturated substitution in Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase at Ile705 position produced three chair-boat-chair (C-B-C) truncated tricyclic compounds, two 17 alpha-exocyclic protosteryl intermediates, two protosteryl C-17 truncated rearranged intermediates and the normal biosynthetic product, lanosterol. These results indicated the importance of the Ile705 residue in affecting lanosterol's C/D ring stabilization including 6-6-5 tricyclic and protosteryl C-17 cations and 17 alpha/beta-exocyclic side chain stereochemistry. | en_US |
| dc.identifier.doi | 10.1039/c0ob00582g | en_US |
| dc.identifier.issn | 1477-0520 | en_US |
| dc.identifier.journal | ORGANIC & BIOMOLECULAR CHEMISTRY | en_US |
| dc.identifier.uri | http://dx.doi.org/10.1039/c0ob00582g | en_US |
| dc.identifier.uri | https://ir.lib.nycu.edu.tw/handle/11536/26104 | |
| dc.identifier.wosnumber | WOS:000286895900021 | |
| dc.language.iso | en_US | en_US |
| dc.title | Mutation of isoleucine 705 of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae affects lanosterol's C/D-ring cyclization and 17 alpha/beta-exocyclic side chain stereochemistry | en_US |
| dc.type | Article | en_US |