Pregnenolonyl-alpha-glucoside exhibits marked anti-cancer and CYP17A1 enzymatic inhibitory activities
| dc.citation.epage | 1736 | en_US |
| dc.citation.issue | 11 | en_US |
| dc.citation.spage | 1733 | en_US |
| dc.citation.volume | 56 | en_US |
| dc.citation.woscount | 0 | en_US |
| dc.contributor.author | Chou, Feng-Pai | en_US |
| dc.contributor.author | Hsu, Wen-Chen | en_US |
| dc.contributor.author | Huang, Sheng-Cih | en_US |
| dc.contributor.author | Chang, Chin-Yuan | en_US |
| dc.contributor.author | Chiou, Ya-Sheng | en_US |
| dc.contributor.author | Tsai, Chia-Tse | en_US |
| dc.contributor.author | Lyu, Jason WenJay | en_US |
| dc.contributor.author | Chen, Wei-Ting | en_US |
| dc.contributor.author | Wu, Tung-Kung | en_US |
| dc.contributor.department | 交大名義發表 | zh_TW |
| dc.contributor.department | 生物科技學系 | zh_TW |
| dc.contributor.department | National Chiao Tung University | en_US |
| dc.contributor.department | Department of Biological Science and Technology | en_US |
| dc.date.accessioned | 2020-03-02T03:23:27Z | |
| dc.date.available | 2020-03-02T03:23:27Z | |
| dc.date.issued | 2020-02-07 | en_US |
| dc.description.abstract | We report here that pregnenolonyl-alpha-glucoside (2), a steryl glycoside synthesized directly from pregnenolone and glucose via a consecutive multienzyme-catalyzed process, exhibits marked dose-dependent cytotoxic activity against HT29, AGS, and ES-2 cells with IC50 values of 23.5 to 50.9 mu M. An in vitro CYP17A1 binding pattern assay and protein-ligand docking model support that 2, like abiraterone, binds in the active site heme iron pocket of CYP17A1. | en_US |
| dc.identifier.doi | 10.1039/c9cc09415f | en_US |
| dc.identifier.issn | 1359-7345 | en_US |
| dc.identifier.journal | CHEMICAL COMMUNICATIONS | en_US |
| dc.identifier.uri | http://dx.doi.org/10.1039/c9cc09415f | en_US |
| dc.identifier.uri | https://ir.lib.nycu.edu.tw/handle/11536/153728 | |
| dc.identifier.wosnumber | WOS:000513177300024 | en_US |
| dc.language.iso | en_US | en_US |
| dc.title | Pregnenolonyl-alpha-glucoside exhibits marked anti-cancer and CYP17A1 enzymatic inhibitory activities | en_US |
| dc.type | Article | en_US |
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