Synthesis of structurally diverse benzimidazolyl benzimidazolones by application of soluble polymer support
| dc.citation.epage | 6394 | en_US |
| dc.citation.issue | 27 | en_US |
| dc.citation.spage | 6387 | en_US |
| dc.citation.volume | 64 | en_US |
| dc.citation.woscount | 7 | |
| dc.contributor.author | Chen, Hsia-Yuan | en_US |
| dc.contributor.author | Kulkarni, Manohar V. | en_US |
| dc.contributor.author | Chen, Chih-Hau | en_US |
| dc.contributor.author | Sun, Chung-Ming | en_US |
| dc.contributor.department | 應用化學系 | zh_TW |
| dc.contributor.department | Department of Applied Chemistry | en_US |
| dc.date.accessioned | 2014-12-08T15:11:20Z | |
| dc.date.available | 2014-12-08T15:11:20Z | |
| dc.date.issued | 2008-06-30 | en_US |
| dc.description.abstract | Chemical stability and reactivity of a bifunctional polymer conjugate containing an ortho-amino arylamide linkage have been successfully exploited to achieve a parallel synthesis of methoxycarbonylated head-tail bis-benzimidazoles. Regioselective alkylation of the two nitrogens in the benzimidazolone moiety has been carried out by ipso-fluoro displacement, and N-alkylation to generate two diversities. Cleavage of the polymer support has resulted in two libraries of di- and tri-substituted benzimidazolyl benzimidazolones in high purity and high yield. All reaction steps have been monitored by (1)H NMR on the support directly. (c) 2008 Elsevier Ltd. All rights reserved. | en_US |
| dc.identifier.doi | 10.1016/j.tet.2008.04.081 | en_US |
| dc.identifier.issn | 0040-4020 | en_US |
| dc.identifier.journal | TETRAHEDRON | en_US |
| dc.identifier.uri | http://dx.doi.org/10.1016/j.tet.2008.04.081 | en_US |
| dc.identifier.uri | https://ir.lib.nycu.edu.tw/handle/11536/8694 | |
| dc.identifier.wosnumber | WOS:000256895100029 | |
| dc.language.iso | en_US | en_US |
| dc.title | Synthesis of structurally diverse benzimidazolyl benzimidazolones by application of soluble polymer support | en_US |
| dc.type | Article | en_US |