Synthesis of alpha-galactosyl ceramide and the related glycolipids for evaluation of their activities on mouse splenocytes
| dc.citation.epage | 1862 | en_US |
| dc.citation.issue | 7 | en_US |
| dc.citation.spage | 1855 | en_US |
| dc.citation.volume | 61 | en_US |
| dc.citation.woscount | 61 | |
| dc.contributor.author | Fan, GT | en_US |
| dc.contributor.author | Pan, YS | en_US |
| dc.contributor.author | Lu, KC | en_US |
| dc.contributor.author | Cheng, YP | en_US |
| dc.contributor.author | Lin, WC | en_US |
| dc.contributor.author | Lin, S | en_US |
| dc.contributor.author | Lin, CH | en_US |
| dc.contributor.author | Wong, CH | en_US |
| dc.contributor.author | Fang, JM | en_US |
| dc.contributor.author | Lin, CC | en_US |
| dc.contributor.department | 應用化學系 | zh_TW |
| dc.contributor.department | Department of Applied Chemistry | en_US |
| dc.date.accessioned | 2014-12-08T15:19:42Z | |
| dc.date.available | 2014-12-08T15:19:42Z | |
| dc.date.issued | 2005-02-14 | en_US |
| dc.description.abstract | Phytosphingosine and its short-chain analog were efficiently synthesized with 19% overall yield in 10 steps, respectively, starting from an inexpensive D-lyxose. Galactosyl donors of sulfide and phosphite types bearing benzoyl protecting groups of 4- and 6OH underwent glycosylation in excellent alpha-anomeric selectivity. A variety of alpha-galactosyl, fucosyl and glucosyl ceramides and serine-type lipids were prepared, and their activities involved in the proliferation of mouse splenocytes and the expression of cytokines were elucidated. Besides alpha-galactosyl ceramides, a galactosyl serine-type lipid also exhibited substantial effect on the expression of cytokines IFN-gamma and IL-4. (C) 2004 Elsevier Ltd. All rights reserved. | en_US |
| dc.identifier.doi | 10.1016/j.tet.2004.12.027 | en_US |
| dc.identifier.issn | 0040-4020 | en_US |
| dc.identifier.journal | TETRAHEDRON | en_US |
| dc.identifier.uri | http://dx.doi.org/10.1016/j.tet.2004.12.027 | en_US |
| dc.identifier.uri | https://ir.lib.nycu.edu.tw/handle/11536/14003 | |
| dc.identifier.wosnumber | WOS:000226915200024 | |
| dc.language.iso | en_US | en_US |
| dc.subject | phytosphingosine | en_US |
| dc.subject | alpha-galactosyl ceramide | en_US |
| dc.subject | immuno stimulator | en_US |
| dc.subject | glycolipid | en_US |
| dc.title | Synthesis of alpha-galactosyl ceramide and the related glycolipids for evaluation of their activities on mouse splenocytes | en_US |
| dc.type | Article | en_US |