Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins
| dc.citation.epage | 2188 | en_US |
| dc.citation.issue | 10 | en_US |
| dc.citation.spage | 2178 | en_US |
| dc.citation.volume | 43 | en_US |
| dc.citation.woscount | 32 | |
| dc.contributor.author | Kalkhambkar, Rajesh G. | en_US |
| dc.contributor.author | Kulkarni, Geeta M. | en_US |
| dc.contributor.author | Kamanavalli, Chandrappa M. | en_US |
| dc.contributor.author | Premkumar, N. | en_US |
| dc.contributor.author | Asdaq, S. M. B. | en_US |
| dc.contributor.author | Sun, Chung Ming | en_US |
| dc.contributor.department | 應用化學系 | zh_TW |
| dc.contributor.department | Department of Applied Chemistry | en_US |
| dc.date.accessioned | 2014-12-08T15:10:50Z | |
| dc.date.available | 2014-12-08T15:10:50Z | |
| dc.date.issued | 2008-10-01 | en_US |
| dc.description.abstract | A series of new fluorinated coumarins and 1-aza coumarins have been synthesized and the presence of fluorine in these molecules and its effect on their anti-microbial, anti-inflammatory and analgesic activities are discussed. The results of bioassay showed that these newly synthesized compounds containing fluorine exhibit moderate analgesic and excellent anti-inflammatory and potential anti-bacterial and anti-fungal activities, compared to the other halogenated compounds. All the newly synthesized compounds were characterized by elemental analysis, IR, (1)H NMR, (13)C NMR, (19)F NMR, EI-MS, and FAB-MS. The ORTEP diagram of one of the compounds is reported herein. (C) 2007 Elsevier Masson SAS. All rights reserved. | en_US |
| dc.identifier.doi | 10.1016/j.ejmech.2007.08.007 | en_US |
| dc.identifier.issn | 0223-5234 | en_US |
| dc.identifier.journal | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | en_US |
| dc.identifier.uri | http://dx.doi.org/10.1016/j.ejmech.2007.08.007 | en_US |
| dc.identifier.uri | https://ir.lib.nycu.edu.tw/handle/11536/8287 | |
| dc.identifier.wosnumber | WOS:000260898800015 | |
| dc.language.iso | en_US | en_US |
| dc.subject | Fluorinated coumarin | en_US |
| dc.subject | Fluorinated 1-aza coumarin | en_US |
| dc.subject | Anti-bacterial | en_US |
| dc.subject | Anti-fungal | en_US |
| dc.subject | Analgesic | en_US |
| dc.subject | Anti-inflammatory | en_US |
| dc.title | Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins | en_US |
| dc.type | Article | en_US |