Identification and characterization of KvgAS, a two-component system in Klebsiella pneumoniae CG43
| dc.citation.epage | 126 | en_US |
| dc.citation.issue | 1 | en_US |
| dc.citation.spage | 121 | en_US |
| dc.citation.volume | 218 | en_US |
| dc.citation.woscount | 8 | |
| dc.contributor.author | Lai, YC | en_US |
| dc.contributor.author | Lin, GT | en_US |
| dc.contributor.author | Yang, SL | en_US |
| dc.contributor.author | Chang, HY | en_US |
| dc.contributor.author | Peng, HL | en_US |
| dc.contributor.department | 生物科技學系 | zh_TW |
| dc.contributor.department | Department of Biological Science and Technology | en_US |
| dc.date.accessioned | 2014-12-08T15:41:23Z | |
| dc.date.available | 2014-12-08T15:41:23Z | |
| dc.date.issued | 2003-01-21 | en_US |
| dc.description.abstract | A two-component system encoding gene cluster kvgAS that is present only in virulent Klebsiella pneumoniae CG43 was isolated and its sequence determined. RT-PCR and Southern analysis demonstrated that kvgAS is organized as an operon. No apparent effect of a kvgS deletion on bacterial virulence was observed in a mouse peritonitis model. In the presence of paraquat or 2,2-dipyridyl, the activity of kvgAS promoter in the kvgS mutant was found to be reduced to half of the level in the wild-type strain. The data suggest that the KvgAS system is autoregulated and plays a role in countering free radical stresses and sensing iron-limiting conditions. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved. | en_US |
| dc.identifier.doi | 10.1016/S0378-1097(02)01120-5 | en_US |
| dc.identifier.issn | 0378-1097 | en_US |
| dc.identifier.journal | FEMS MICROBIOLOGY LETTERS | en_US |
| dc.identifier.uri | http://dx.doi.org/10.1016/S0378-1097(02)01120-5 | en_US |
| dc.identifier.uri | https://ir.lib.nycu.edu.tw/handle/11536/28157 | |
| dc.identifier.wosnumber | WOS:000180990700018 | |
| dc.language.iso | en_US | en_US |
| dc.subject | two-component system | en_US |
| dc.subject | response regulator | en_US |
| dc.subject | histidine kinase | en_US |
| dc.subject | Klebsiella gene | en_US |
| dc.title | Identification and characterization of KvgAS, a two-component system in Klebsiella pneumoniae CG43 | en_US |
| dc.type | Article | en_US |