In situ doxorubicin-CaP shell formation on amphiphilic gelatin-iron oxide core as a multifunctional drug delivery system with improved cytocompatibility, pH-responsive drug release and MR imaging
| dc.citation.epage | 5368 | en_US |
| dc.citation.issue | 2 | en_US |
| dc.citation.spage | 5360 | en_US |
| dc.citation.volume | 9 | en_US |
| dc.citation.woscount | 14 | |
| dc.contributor.author | Li, W. -M. | en_US |
| dc.contributor.author | Chen, S. -Y. | en_US |
| dc.contributor.author | Liu, D. -M. | en_US |
| dc.contributor.department | 材料科學與工程學系 | zh_TW |
| dc.contributor.department | Department of Materials Science and Engineering | en_US |
| dc.date.accessioned | 2014-12-08T15:29:31Z | |
| dc.date.available | 2014-12-08T15:29:31Z | |
| dc.date.issued | 2013-02-01 | en_US |
| dc.description.abstract | An amphiphilic gelatin-iron oxide core/calcium phosphate shell (AGIO@CaP-DOX) nanoparticle was successfully synthesized as an efficient anti-cancer drug delivery system, where doxorubicin (DOX) as a model molecule was encapsulated by electrolytic co-deposition during CaP shell formation. The shell of CaP precipitate played a pivotal role, not only in acting as a drug depot, but also in rendering the drug release rate in a highly pH-dependent controlled manner. Together with MR imaging, highly biocompatible drug-carrying CaP shell and efficient cellular internalization, the AGIO@CaP-DOX nanoparticles developed in this study area promising multifunctional nanodevice for nanotherapeutic approaches. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. | en_US |
| dc.identifier.doi | 10.1016/j.actbio.2012.09.023 | en_US |
| dc.identifier.issn | 1742-7061 | en_US |
| dc.identifier.journal | ACTA BIOMATERIALIA | en_US |
| dc.identifier.uri | http://dx.doi.org/10.1016/j.actbio.2012.09.023 | en_US |
| dc.identifier.uri | https://ir.lib.nycu.edu.tw/handle/11536/21233 | |
| dc.identifier.wosnumber | WOS:000315170800045 | |
| dc.language.iso | en_US | en_US |
| dc.subject | Calcium phosphate | en_US |
| dc.subject | pH-sensitivity | en_US |
| dc.subject | Drug release | en_US |
| dc.subject | Amphiphilic gelatin | en_US |
| dc.subject | MR imaging | en_US |
| dc.title | In situ doxorubicin-CaP shell formation on amphiphilic gelatin-iron oxide core as a multifunctional drug delivery system with improved cytocompatibility, pH-responsive drug release and MR imaging | en_US |
| dc.type | Article | en_US |