Measuring the flexibility of immunoglobulin by gold nanoparticles
| dc.citation.epage | 2471 | en_US |
| dc.citation.issue | 11 | en_US |
| dc.citation.spage | 2467 | en_US |
| dc.citation.volume | 6 | en_US |
| dc.citation.woscount | 21 | |
| dc.contributor.author | Huang, G. Steven | en_US |
| dc.contributor.author | Chen, Yu-Shiun | en_US |
| dc.contributor.author | Yeh, Hsiao-Wei | en_US |
| dc.contributor.department | 材料科學與工程學系奈米科技碩博班 | zh_TW |
| dc.contributor.department | 奈米科技中心 | zh_TW |
| dc.contributor.department | Graduate Program of Nanotechnology , Department of Materials Science and Engineering | en_US |
| dc.contributor.department | Center for Nanoscience and Technology | en_US |
| dc.date.accessioned | 2014-12-08T15:15:23Z | |
| dc.date.available | 2014-12-08T15:15:23Z | |
| dc.date.issued | 2006-11-08 | en_US |
| dc.description.abstract | We measured the flexibility of Fab and Fc arms of immunoglobulin using gold nanoparticles (GNPs). Enzyme-linked immunosorbent assay was performed to measure the affinity of anti-5 nm GNP antiserum against various sizes of GNPs. The flexibility of Fc was also measured by electron microscopy. The restricted binding affinity indicated that only a very limited amount of freedom was allowed for the Fab-Fab hinge, while Fab-Fc showed a much larger degree of freedom. | en_US |
| dc.identifier.doi | 10.1021/nl061598x | en_US |
| dc.identifier.issn | 1530-6984 | en_US |
| dc.identifier.journal | NANO LETTERS | en_US |
| dc.identifier.uri | http://dx.doi.org/10.1021/nl061598x | en_US |
| dc.identifier.uri | https://ir.lib.nycu.edu.tw/handle/11536/11555 | |
| dc.identifier.wosnumber | WOS:000241856700014 | |
| dc.language.iso | en_US | en_US |
| dc.title | Measuring the flexibility of immunoglobulin by gold nanoparticles | en_US |
| dc.type | Article | en_US |