Palladium-catalyzed alpha-arylation of indolin-3-ones
| dc.citation.epage | 4663 | en_US |
| dc.citation.issue | 34 | en_US |
| dc.citation.spage | 4660 | en_US |
| dc.citation.volume | 56 | en_US |
| dc.citation.woscount | 0 | en_US |
| dc.contributor.author | Chang, Yu-Hsuan | en_US |
| dc.contributor.author | Peng, Wan-Ling | en_US |
| dc.contributor.author | Chen, I-Chia | en_US |
| dc.contributor.author | Hsu, Hsin-Yun | en_US |
| dc.contributor.author | Wu, Yen-Ku | en_US |
| dc.contributor.department | 應用化學系 | zh_TW |
| dc.contributor.department | Department of Applied Chemistry | en_US |
| dc.date.accessioned | 2020-07-01T05:21:15Z | |
| dc.date.available | 2020-07-01T05:21:15Z | |
| dc.date.issued | 2020-04-30 | en_US |
| dc.description.abstract | A method for the catalytic alpha-arylation of indolin-3-ones was developed. The catalytic system comprising Pd(dba)(2) and PAd(3) was found to be optimal for the transformation. The protocol features broad functional group compatibility in that a range of arylated indoxyl derivatives bearing a fully substituted carbon center was synthesized with high efficiency. A preliminary bioassay study revealed that the selected indole-substituted indolin-3-ones exhibit favorable cytotoxic activities against HCT-116 cancer cell line. | en_US |
| dc.identifier.doi | 10.1039/d0cc00435a | en_US |
| dc.identifier.issn | 1359-7345 | en_US |
| dc.identifier.journal | CHEMICAL COMMUNICATIONS | en_US |
| dc.identifier.uri | http://dx.doi.org/10.1039/d0cc00435a | en_US |
| dc.identifier.uri | https://ir.lib.nycu.edu.tw/handle/11536/154321 | |
| dc.identifier.wosnumber | WOS:000530725500003 | en_US |
| dc.language.iso | en_US | en_US |
| dc.title | Palladium-catalyzed alpha-arylation of indolin-3-ones | en_US |
| dc.type | Article | en_US |
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