A new approach to nicotine: Symmetry consideration for synthesis design
| dc.citation.epage | 2716 | en_US |
| dc.citation.issue | 10 | en_US |
| dc.citation.spage | 2712 | en_US |
| dc.citation.volume | 87 | en_US |
| dc.citation.woscount | 6 | |
| dc.contributor.author | Ho, TL | en_US |
| dc.contributor.author | Kuzakov, EV | en_US |
| dc.contributor.department | 應用化學系 | zh_TW |
| dc.contributor.department | Department of Applied Chemistry | en_US |
| dc.date.accessioned | 2014-12-08T15:39:54Z | |
| dc.date.available | 2014-12-08T15:39:54Z | |
| dc.date.issued | 2004 | en_US |
| dc.description.abstract | A synthesis of nicotyrine (9), and hence formally racemic nicotine, was carried out by elaboration of the 1:1 adduct 2 of cycloocta-1,5-diene and chlorosulfonyl isocyanate (ClSO2-NCO). Transformation of adduct 2 into carbamate 4 was followed by ozonolysis, tosylation, and NaH treatment, which led to pyrrolidinylpiperidinone 6. LiAlH4 Reduction, debenzylation, and aromatization yielded 2. | en_US |
| dc.identifier.doi | 10.1002/hlca.200490241 | en_US |
| dc.identifier.issn | 0018-019X | en_US |
| dc.identifier.journal | HELVETICA CHIMICA ACTA | en_US |
| dc.identifier.uri | http://dx.doi.org/10.1002/hlca.200490241 | en_US |
| dc.identifier.uri | https://ir.lib.nycu.edu.tw/handle/11536/27261 | |
| dc.identifier.wosnumber | WOS:000224935400020 | |
| dc.language.iso | en_US | en_US |
| dc.title | A new approach to nicotine: Symmetry consideration for synthesis design | en_US |
| dc.type | Article | en_US |