NMR study of hydrogen bonding association of 2-isopropylphenol in carbon tetrachloride, acetone, dimethyl sulphoxide and acetonitrile

Abstract

This study investigates the association of 2-isopropylphenol through hydrogen bonding in carbon tetrachloride, [H-2(6)]acetone, [H-2(3)]acetonitrile and [H-2(6)]dimethyl sulphoxide by using high resolution nuclear magnetic resonance spectroscopy. Chemical shifts of the hydroxyl proton were measured over a wide range of temperature and concentration. The chemical shift data were treated by a graphical method to determine the monomer shift, dimer shift and dimerization constant. The enthalpy and entropy of dimerization were determined via a van't Hoff plot from the temperature variation of the dimerization constant.